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    Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area

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    Authors
    Moormann, Ann M.
    John, Chandy C.
    Sumba, Peter Odada
    Tisch, Daniel J.
    Embury, Paula E.
    Kazura, James W.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2006-04-12
    Keywords
    Adolescent
    Adult
    Animals
    Antigens, Protozoan
    Child
    Child, Preschool
    Cross-Sectional Studies
    Endemic Diseases
    Female
    Humans
    Interferon-gamma
    Interleukin-10
    Kenya
    *Malaria Vaccines
    Malaria, Falciparum
    Male
    Plasmodium falciparum
    Protozoan Proteins
    Biostatistics
    Epidemiology
    Health Services Research
    Immunology and Infectious Disease
    Pediatrics
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    Abstract
    The stability of anti-malarial immunity will influence the interpretation of immunologic endpoints during malaria vaccine trials conducted in endemic areas. Therefore, we evaluated cytokine responses to Plasmodium falciparum liver stage antigen-1 (LSA-1) and thrombospondin-related adhesive protein (TRAP) by Kenyans from a holoendemic area at a 9-month interval. The proportion of adults with interferon-gamma (IFN-gamma) responses to 9-mer LSA-1 peptides was similar at both time-points, whereas responses from children decreased (P < 0.05). Response to the longer, 23-mer LSA-1 peptide was variable, decreasing in adults and children over time (P < 0.02 and P < 0.001, respectively). The proportion of children with IFN-gamma responses to either antigen at the second time-point was significantly lower than that of adults, yet more adults responded to 9-mer TRAP peptides (P < 0.02). In contrast, the proportion of interleukin-10 responses to LSA-1 and TRAP was similar at both time-points for both age groups. Most noteworthy was that even when the repeat cross-sectional frequency of cytokine responses was the same, these responses were not generated by the same individuals. This suggests that cytokine responses to LSA-1 and TRAP are transient under natural exposure conditions.
    Source
    Am J Trop Med Hyg. 2006 Apr;74(4):585-90. Link to article on publisher's site
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47252
    PubMed ID
    16606988
    Related Resources
    Link to Article in PubMed
    Rights
    Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
    Collections
    Population and Quantitative Health Sciences Publications

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