Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
Authors
Asito, Amolo S.Moormann, Ann M.
Chelimo, Kiprotich
Ng'ang'a, Zipporah W.
Ploutz-Snyder, Robert
Rochford, Rosemary A.
Document Type
Journal ArticlePublication Date
2008-11-21Keywords
AnimalsAntigens, CD19
Antigens, CD38
B-Lymphocytes
Case-Control Studies
Child, Preschool
Flow Cytometry
Humans
Immunoglobulin D
Immunologic Memory
Lymphocyte Subsets
Malaria, Falciparum
Neprilysin
Plasmodium falciparum
Biostatistics
Epidemiology
Health Services Research
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
BACKGROUND: The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. METHODS: Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. RESULTS: There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset. CONCLUSION: Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.Source
Malar J. 2008 Nov 18;7:238. Link to article on publisher's siteDOI
10.1186/1475-2875-7-238Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47265PubMed ID
19019204Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1186/1475-2875-7-238