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    Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children

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    Authors
    Asito, Amolo S.
    Moormann, Ann M.
    Chelimo, Kiprotich
    Ng'ang'a, Zipporah W.
    Ploutz-Snyder, Robert
    Rochford, Rosemary A.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2008-11-21
    Keywords
    Animals
    Antigens, CD19
    Antigens, CD38
    B-Lymphocytes
    Case-Control Studies
    Child, Preschool
    Flow Cytometry
    Humans
    Immunoglobulin D
    Immunologic Memory
    Lymphocyte Subsets
    Malaria, Falciparum
    Neprilysin
    Plasmodium falciparum
    Biostatistics
    Epidemiology
    Health Services Research
    Immunology and Infectious Disease
    Pediatrics
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    Abstract
    BACKGROUND: The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. METHODS: Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. RESULTS: There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset. CONCLUSION: Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.
    Source
    Malar J. 2008 Nov 18;7:238. Link to article on publisher's site
    DOI
    10.1186/1475-2875-7-238
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47265
    PubMed ID
    19019204
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1186/1475-2875-7-238
    Scopus Count
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    Population and Quantitative Health Sciences Publications

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