Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
AuthorsAsito, Amolo S.
Moormann, Ann M.
Ng'ang'a, Zipporah W.
Rochford, Rosemary A.
UMass Chan AffiliationsDepartment of Pediatrics
Department of Quantitative Health Sciences
Document TypeJournal Article
Health Services Research
Immunology and Infectious Disease
MetadataShow full item record
AbstractBACKGROUND: The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. METHODS: Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. RESULTS: There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset. CONCLUSION: Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.
SourceMalar J. 2008 Nov 18;7:238. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/47265
Related ResourcesLink to Article in PubMed