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    Illicit drug use in young adults and subsequent decline in general health: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

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    Authors
    Kertesz, Stefan G.
    Pletcher, Mark J.
    Safford, Monika M.
    Halanych, Jewell H.
    Kirk, Katharine
    Schumacher, Joseph
    Sidney, Stephen
    Kiefe, Catarina I.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2006-12-02
    Keywords
    Adult
    African Continental Ancestry Group
    Alabama
    California
    Cohort Studies
    Coronary Disease
    European Continental Ancestry Group
    Female
    *Health Status
    Humans
    Male
    Multivariate Analysis
    Risk Assessment
    Socioeconomic Factors
    *Street Drugs
    Substance-Related Disorders
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    http://dx.doi.org/10.1016/j.drugalcdep.2006.10.017
    Abstract
    BACKGROUND: The long-term health consequences of drug use among healthy young adults in the general population are not well described. We assessed whether drug use predicted decline in general self-rated health (GSRH) in a community-based cohort, healthy at baseline. METHODS: A prospective cohort of 3124 young adults (20-32 years old) from four US cities, the Coronary Artery Risk Development in Young Adults Study, was followed from 1987/1988 to 2000/2001. All reported "Good" or better GSRH at baseline, with reassessment in 2000/2001. Drug use in 1987/1988 was as follows: 812 participants were Never Users; 1554 Past Users Only; 503 Current Marijuana Users Only; 255 Current Hard Drug Users (e.g. cocaine, amphetamines, opiates). Analyses measured the association of drug use (1987/1988) with decline to "Fair" or "Poor" GSRH in 2000/2001, adjusting for biological and psychosocial covariates. RESULTS: Reporting health decline were: 7.2% of Never Users; 6.5%, Past Use Only; 7.0%, Current Marijuana Only; 12.6%, Current Hard Drugs (p<0.01). After multivariable adjustment, Current Hard Drug Use in 1987/1988 remained associated with health decline (Odds Ratio (OR), referent Never Use: 1.83, 95% confidence interval (CI) 1.07-3.12). The health decline associated with Current Hard Drugs appeared to be partly mediated by tobacco smoking in 2000/2001, which independently predicted health decline (OR 1.66, 95% CI 1.08-2.50) and weakened the apparent effect of Current Hard Drugs (OR 1.21, 95% CI 0.62-2.36). CONCLUSIONS: Hard drug use in healthy young adults, even when hard drug use stops, is associated with a subsequent decrease in general self-rated health that may be partially explained by persistent tobacco use.
    Source
    Drug Alcohol Depend. 2007 May 11;88(2-3):224-33. Epub 2006 Nov 29. Link to article on publisher's site
    DOI
    10.1016/j.drugalcdep.2006.10.017
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47269
    PubMed ID
    17137732
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.drugalcdep.2006.10.017
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