Illicit drug use in young adults and subsequent decline in general health: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
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Authors
Kertesz, Stefan G.Pletcher, Mark J.
Safford, Monika M.
Halanych, Jewell H.
Kirk, Katharine
Schumacher, Joseph
Sidney, Stephen
Kiefe, Catarina I.
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2006-12-02Keywords
AdultAfrican Continental Ancestry Group
Alabama
California
Cohort Studies
Coronary Disease
European Continental Ancestry Group
Female
*Health Status
Humans
Male
Multivariate Analysis
Risk Assessment
Socioeconomic Factors
*Street Drugs
Substance-Related Disorders
Bioinformatics
Biostatistics
Epidemiology
Health Services Research
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Show full item recordAbstract
BACKGROUND: The long-term health consequences of drug use among healthy young adults in the general population are not well described. We assessed whether drug use predicted decline in general self-rated health (GSRH) in a community-based cohort, healthy at baseline. METHODS: A prospective cohort of 3124 young adults (20-32 years old) from four US cities, the Coronary Artery Risk Development in Young Adults Study, was followed from 1987/1988 to 2000/2001. All reported "Good" or better GSRH at baseline, with reassessment in 2000/2001. Drug use in 1987/1988 was as follows: 812 participants were Never Users; 1554 Past Users Only; 503 Current Marijuana Users Only; 255 Current Hard Drug Users (e.g. cocaine, amphetamines, opiates). Analyses measured the association of drug use (1987/1988) with decline to "Fair" or "Poor" GSRH in 2000/2001, adjusting for biological and psychosocial covariates. RESULTS: Reporting health decline were: 7.2% of Never Users; 6.5%, Past Use Only; 7.0%, Current Marijuana Only; 12.6%, Current Hard Drugs (p<0.01). After multivariable adjustment, Current Hard Drug Use in 1987/1988 remained associated with health decline (Odds Ratio (OR), referent Never Use: 1.83, 95% confidence interval (CI) 1.07-3.12). The health decline associated with Current Hard Drugs appeared to be partly mediated by tobacco smoking in 2000/2001, which independently predicted health decline (OR 1.66, 95% CI 1.08-2.50) and weakened the apparent effect of Current Hard Drugs (OR 1.21, 95% CI 0.62-2.36). CONCLUSIONS: Hard drug use in healthy young adults, even when hard drug use stops, is associated with a subsequent decrease in general self-rated health that may be partially explained by persistent tobacco use.Source
Drug Alcohol Depend. 2007 May 11;88(2-3):224-33. Epub 2006 Nov 29. Link to article on publisher's siteDOI
10.1016/j.drugalcdep.2006.10.017Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47269PubMed ID
17137732Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.drugalcdep.2006.10.017