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dc.contributor.authorKertesz, Stefan G.
dc.contributor.authorPletcher, Mark J.
dc.contributor.authorSafford, Monika M.
dc.contributor.authorHalanych, Jewell H.
dc.contributor.authorKirk, Katharine
dc.contributor.authorSchumacher, Joseph
dc.contributor.authorSidney, Stephen
dc.contributor.authorKiefe, Catarina I.
dc.date2022-08-11T08:10:40.000
dc.date.accessioned2022-08-23T17:15:53Z
dc.date.available2022-08-23T17:15:53Z
dc.date.issued2006-12-02
dc.date.submitted2010-04-27
dc.identifier.citationDrug Alcohol Depend. 2007 May 11;88(2-3):224-33. Epub 2006 Nov 29. <a href="http://dx.doi.org/10.1016/j.drugalcdep.2006.10.017">Link to article on publisher's site</a>
dc.identifier.issn0376-8716 (Linking)
dc.identifier.doi10.1016/j.drugalcdep.2006.10.017
dc.identifier.pmid17137732
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47269
dc.description.abstractBACKGROUND: The long-term health consequences of drug use among healthy young adults in the general population are not well described. We assessed whether drug use predicted decline in general self-rated health (GSRH) in a community-based cohort, healthy at baseline. METHODS: A prospective cohort of 3124 young adults (20-32 years old) from four US cities, the Coronary Artery Risk Development in Young Adults Study, was followed from 1987/1988 to 2000/2001. All reported "Good" or better GSRH at baseline, with reassessment in 2000/2001. Drug use in 1987/1988 was as follows: 812 participants were Never Users; 1554 Past Users Only; 503 Current Marijuana Users Only; 255 Current Hard Drug Users (e.g. cocaine, amphetamines, opiates). Analyses measured the association of drug use (1987/1988) with decline to "Fair" or "Poor" GSRH in 2000/2001, adjusting for biological and psychosocial covariates. RESULTS: Reporting health decline were: 7.2% of Never Users; 6.5%, Past Use Only; 7.0%, Current Marijuana Only; 12.6%, Current Hard Drugs (p<0.01). After multivariable adjustment, Current Hard Drug Use in 1987/1988 remained associated with health decline (Odds Ratio (OR), referent Never Use: 1.83, 95% confidence interval (CI) 1.07-3.12). The health decline associated with Current Hard Drugs appeared to be partly mediated by tobacco smoking in 2000/2001, which independently predicted health decline (OR 1.66, 95% CI 1.08-2.50) and weakened the apparent effect of Current Hard Drugs (OR 1.21, 95% CI 0.62-2.36). CONCLUSIONS: Hard drug use in healthy young adults, even when hard drug use stops, is associated with a subsequent decrease in general self-rated health that may be partially explained by persistent tobacco use.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17137732&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.drugalcdep.2006.10.017
dc.subjectAdult
dc.subjectAfrican Continental Ancestry Group
dc.subjectAlabama
dc.subjectCalifornia
dc.subjectCohort Studies
dc.subjectCoronary Disease
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subject*Health Status
dc.subjectHumans
dc.subjectMale
dc.subjectMultivariate Analysis
dc.subjectRisk Assessment
dc.subjectSocioeconomic Factors
dc.subject*Street Drugs
dc.subjectSubstance-Related Disorders
dc.subjectBioinformatics
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleIllicit drug use in young adults and subsequent decline in general health: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
dc.typeJournal Article
dc.source.journaltitleDrug and alcohol dependence
dc.source.volume88
dc.source.issue2-3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/41
dc.identifier.contextkey1287786
html.description.abstract<p>BACKGROUND: The long-term health consequences of drug use among healthy young adults in the general population are not well described. We assessed whether drug use predicted decline in general self-rated health (GSRH) in a community-based cohort, healthy at baseline.</p> <p>METHODS: A prospective cohort of 3124 young adults (20-32 years old) from four US cities, the Coronary Artery Risk Development in Young Adults Study, was followed from 1987/1988 to 2000/2001. All reported "Good" or better GSRH at baseline, with reassessment in 2000/2001. Drug use in 1987/1988 was as follows: 812 participants were Never Users; 1554 Past Users Only; 503 Current Marijuana Users Only; 255 Current Hard Drug Users (e.g. cocaine, amphetamines, opiates). Analyses measured the association of drug use (1987/1988) with decline to "Fair" or "Poor" GSRH in 2000/2001, adjusting for biological and psychosocial covariates.</p> <p>RESULTS: Reporting health decline were: 7.2% of Never Users; 6.5%, Past Use Only; 7.0%, Current Marijuana Only; 12.6%, Current Hard Drugs (p<0.01). After multivariable adjustment, Current Hard Drug Use in 1987/1988 remained associated with health decline (Odds Ratio (OR), referent Never Use: 1.83, 95% confidence interval (CI) 1.07-3.12). The health decline associated with Current Hard Drugs appeared to be partly mediated by tobacco smoking in 2000/2001, which independently predicted health decline (OR 1.66, 95% CI 1.08-2.50) and weakened the apparent effect of Current Hard Drugs (OR 1.21, 95% CI 0.62-2.36).</p> <p>CONCLUSIONS: Hard drug use in healthy young adults, even when hard drug use stops, is associated with a subsequent decrease in general self-rated health that may be partially explained by persistent tobacco use.</p>
dc.identifier.submissionpathqhs_pp/41
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages224-33


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