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    Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya

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    Authors
    Moormann, Ann M.
    Sumba, Peter Odada
    Tisch, Daniel J.
    Embury, Paula E.
    King, Charles H.
    Kazura, James W.
    John, Chandy C.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2009-08-27
    Keywords
    Adolescent
    Adult
    Animals
    Antigens, Protozoan
    Cells, Cultured
    Enzyme-Linked Immunosorbent Assay
    Gene Expression Regulation
    Humans
    Immunodominant Epitopes
    Interferon-gamma
    Interleukin-10
    Kenya
    Leukocytes, Mononuclear
    Malaria, Falciparum
    Parasitemia
    Plasmodium falciparum
    Prevalence
    Protozoan Proteins
    Time Factors
    Young Adult
    Biostatistics
    Epidemiology
    Health Services Research
    Immunology and Infectious Disease
    Pediatrics
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    Link to Full Text
    http://www.ajtmh.org/cgi/reprint/81/3/489
    Abstract
    Long-term planning to prevent malaria epidemics requires in-depth understanding of immunity to Plasmodium falciparum in areas of unstable transmission. Cytokine responses to immunodominant epitope peptides from liver stage antigen 1 (LSA-1) and thrombospondin-related adhesive protein (TRAP) were evaluated over a nine-month interval in adults and children in Kenya from a malaria epidemic-prone highland area after several years of low transmission. The proportion and magnitude of interferon-gamma ELISPOT responses and the proportion of interleukin-10 responders to LSA-1 and TRAP peptides tended to be higher in adults than children. Frequencies of interferon-gamma responders to these peptides were similar at the two time points, but responses were not consistently generated by the same persons. These results suggest that T cell memory to pre-erythrocytic stage malaria antigens is maintained but may be unavailable for consistent detection in peripheral blood, and that these antigens induce both pro-inflammatory and anti-inflammatory cytokine responses in this population.
    Source
    Am J Trop Med Hyg. 2009 Sep;81(3):489-95. Link to article on publisher's site
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47271
    PubMed ID
    19706920
    Related Resources
    Link to Article in PubMed
    Collections
    Population and Quantitative Health Sciences Publications

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