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dc.contributor.authorMoormann, Ann M.
dc.date2022-08-11T08:10:40.000
dc.date.accessioned2022-08-23T17:15:55Z
dc.date.available2022-08-23T17:15:55Z
dc.date.issued2009-08-21
dc.date.submitted2010-06-08
dc.identifier.citationParasite Immunol. 2009 Sep;31(9):547-59. <a href="http://dx.doi.org/10.1111/j.1365-3024.2009.01137.x">Link to article on publisher's site</a>
dc.identifier.issn0141-9838 (Linking)
dc.identifier.doi10.1111/j.1365-3024.2009.01137.x
dc.identifier.pmid19691558
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47275
dc.description.abstractNaturally acquired immunity to malaria requires repeat infections yet does not engender sterile immunity or long-lasting protective immunologic memory. This renders infants and young children the most susceptible to malaria-induced morbidity and mortality, and the ultimate target for a malaria vaccine. The prevailing paradigm is that infants initially garner protection due to transplacentally transferred anti-malarial antibodies and other intrinsic factors such as foetal haemoglobin. As these wane infants have an insufficient immune repertoire to prevent genetically diverse Plasmodium infections and an inability to control malaria-induced immunopathology. This Review discusses humoral, cell-mediated and innate immune responses to malaria and how each contributes to protection - focusing on how deficiencies in infant and paediatric immune responses might influence malaria vaccine efficacy in this population. In addition, burgeoning evidence suggests a role for inhibitory receptors that limit immunopathology and guide the development of long-lived immunity. Precisely how age or malaria infections influence the function of these regulators is unknown. Therefore the possibility that infants may not have the immune-dexterity to balance effective parasite clearance with timely immune-regulation leading to protective immunologic memory is considered. And thus, malaria vaccines tested in adults and older children may not be predictive for trials conducted in infants.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=19691558&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1111/j.1365-3024.2009.01137.x
dc.subjectAge Factors
dc.subjectChild, Preschool
dc.subjectHumans
dc.subjectImmune System
dc.subjectInfant
dc.subjectMalaria
dc.subjectMalaria Vaccines
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.subjectImmunology and Infectious Disease
dc.subjectPediatrics
dc.titleHow might infant and paediatric immune responses influence malaria vaccine efficacy
dc.typeJournal Article
dc.source.journaltitleParasite immunology
dc.source.volume31
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/415
dc.identifier.contextkey1347946
html.description.abstract<p>Naturally acquired immunity to malaria requires repeat infections yet does not engender sterile immunity or long-lasting protective immunologic memory. This renders infants and young children the most susceptible to malaria-induced morbidity and mortality, and the ultimate target for a malaria vaccine. The prevailing paradigm is that infants initially garner protection due to transplacentally transferred anti-malarial antibodies and other intrinsic factors such as foetal haemoglobin. As these wane infants have an insufficient immune repertoire to prevent genetically diverse Plasmodium infections and an inability to control malaria-induced immunopathology. This Review discusses humoral, cell-mediated and innate immune responses to malaria and how each contributes to protection - focusing on how deficiencies in infant and paediatric immune responses might influence malaria vaccine efficacy in this population. In addition, burgeoning evidence suggests a role for inhibitory receptors that limit immunopathology and guide the development of long-lived immunity. Precisely how age or malaria infections influence the function of these regulators is unknown. Therefore the possibility that infants may not have the immune-dexterity to balance effective parasite clearance with timely immune-regulation leading to protective immunologic memory is considered. And thus, malaria vaccines tested in adults and older children may not be predictive for trials conducted in infants.</p>
dc.identifier.submissionpathqhs_pp/415
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages547-59


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