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    Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study

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    Authors
    Houston, Thomas K.
    Person, Sharina D.
    Pletcher, Mark J.
    Liu, Kiang
    Iribarren, Carlos
    Kiefe, Catarina I.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2006-04-11
    Keywords
    Adult
    Continental Population Groups
    Female
    Glucose Intolerance
    Humans
    Incidence
    Insulin
    Male
    Prospective Studies
    Risk Factors
    Sex Distribution
    Smoking
    Tobacco Smoke Pollution
    United States
    Waist-Hip Ratio
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Abstract
    OBJECTIVE: To assess whether active and passive smokers are more likely than non-smokers to develop clinically relevant glucose intolerance or diabetes. DESIGN: Coronary artery risk development in young adults (CARDIA) is a prospective cohort study begun in 1985-6 with 15 years of follow-up. SETTING: Participants recruited from Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California, USA. PARTICIPANTS: Black and white men and women aged 18-30 years with no glucose intolerance at baseline, including 1386 current smokers, 621 previous smokers, 1452 never smokers with reported exposure to secondhand smoke (validated by serum cotinine concentrations 1-15 ng/ml), and 1113 never smokers with no exposure to secondhand smoke. MAIN OUTCOME MEASURE: Time to development of glucose intolerance (glucose > or = 100 mg/dl or taking antidiabetic drugs) during 15 years of follow-up. RESULTS: Median age at baseline was 25, 55% of participants were women, and 50% were African-American. During follow-up, 16.7% of participants developed glucose intolerance. A graded association existed between smoking exposure and the development of glucose intolerance. The 15 year incidence of glucose intolerance was highest among smokers (21.8%), followed by never smokers with passive smoke exposure (17.2%), and then previous smokers (14.4%); it was lowest for never smokers with no passive smoke exposure (11.5%). Current smokers (hazard ratio 1.65, 95% confidence interval 1.27 to 2.13) and never smokers with passive smoke exposure (1.35, 1.06 to 1.71) remained at higher risk than never smokers without passive smoke exposure after adjustment for multiple baseline sociodemographic, biological, and behavioural factors, but risk in previous smokers was similar to that in never smokers without passive smoke exposure. CONCLUSION: These findings support a role of both active and passive smoking in the development of glucose intolerance in young adulthood.
    Source
    BMJ. 2006 May 6;332(7549):1064-9. Epub 2006 Apr 7. Link to article on publisher's site
    DOI
    10.1136/bmj.38779.584028.55
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47380
    PubMed ID
    16603565
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1136/bmj.38779.584028.55
    Scopus Count
    Collections
    Population and Quantitative Health Sciences Publications

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