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    The effects of recombinant human erythropoietin on functional health and well-being in chronic dialysis patients

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    Authors
    Beusterien, Kathleen M.
    Nissenson, Allen R.
    Port, Friedrich K.
    Kelly, Mary
    Steinwald, Bruce
    Ware, John E. Jr.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    1996-05-01
    Keywords
    Activities of Daily Living
    Adult
    Aged
    Anemia
    control
    Comorbidity
    Continental Population Groups
    Depressive Disorder
    Erythropoietin, Recombinant
    Female
    Heart Failure
    Hematocrit
    Humans
    Kidney Failure, Chronic
    Male
    Middle Aged
    Patient Acceptance of Health Care
    Peritoneal Dialysis
    *Quality of Life
    *Renal Dialysis
    Self Assessment (Psychology)
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://jasn.asnjournals.org/cgi/reprint/7/5/763
    Abstract
    As a component of the open-label, multicenter National Cooperative Recombinant Human Erythropoietin (Epo) Study, the health-related quality-of-life effects of Epo therapy were assessed in 484 dialysis patients who had not previously been treated with Epo therapy (New-to-Epo) and 520 dialysis patients who were already receiving Epo therapy at the time of study enrollment (Old-to-Epo). Using scales from the Medical Outcomes Study 36-item Short Form Health Survey (SF-36), health-related quality of life was assessed on study enrollment (baseline) and at an average of 99 days follow-up. At baseline, SF-36 scores for Old- and New-to-Epo patients were well below those observed in the general population, reflecting substantial impairments in functional status and well-being among patients with chronic renal failure. Significant improvements from baseline to follow-up were observed among New-to-Epo patients in vitality, physical functioning, social functioning, mental health, looking after the home, social life, hobbies, and satisfaction with sexual activity (P < 0.05 for each). The mean improvements in hematocrit values among New-to-Epo and Old-to Epo patients were 4.6 and 0.3, respectively. At the time of follow-up, SF-36 scores for New-to-Epo patients were comparable with those observed among Old-to-Epo patients, whose scores did not change significantly from baseline to follow-up. Analysis of the relationship between Epo therapy, hematocrit values, and health-related quality of life suggest that some of the beneficial quality-of-life effects of Epo are mediated through a change in hematocrit level.
    Source
    J Am Soc Nephrol. 1996 May;7(5):763-73. Link to article on publisher's site
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47389
    PubMed ID
    8738812
    Related Resources
    Link to Article in PubMed
    Collections
    Population and Quantitative Health Sciences Publications

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