Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups
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Authors
Komaroff, Anthony L.Fagioli, Laura R.
Doolittle, Teresa H.
Gandek, Barbara
Gleit, Marcy A.
Guerriero, Rosanne T.
Kornish, R. James II
Ware, Norma C.
Ware, John E. Jr.
Bates, David W.
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
1996-09-01Keywords
Activities of Daily LivingAdult
Depressive Disorder
Diabetes Mellitus, Type 2
Fatigue Syndrome, Chronic
Female
*Health Status
Heart Failure
Humans
Hypertension
Male
Mental Health
Multiple Sclerosis
Myocardial Infarction
Psychometrics
Questionnaires
Biostatistics
Epidemiology
Health Services Research
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Show full item recordAbstract
PURPOSE: To measure the functional status and well-being of patients with chronic fatigue syndrome (CFS), and compare them with those of a general population group and six disease comparison groups. PATIENTS AND METHODS: The subjects of the study were patients with CFS (n = 223) from a CFS clinic, a population-based control sample (n = 2,474), and disease comparison groups with hypertension (n = 2,089), congestive heart failure (n = 216), type II diabetes mellitus (n = 163), acute myocardial infarction (n = 107), multiple sclerosis (n = 25), and depression (n = 502). We measured functional status and well-being using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), which is a self-administered questionnaire in which lower scores are indicative of greater impairment. RESULTS: Patients with CFS had far lower mean scores than the general population control subjects on all eight SF-36 scales. They also scored significantly lower than patients in all the disease comparison groups other than depression on virtually all the scales. When compared with patients with depression, they scored significantly lower on all the scales except for scales measuring mental health and role disability due to emotional problems, on which they scored significantly higher. The two SF-36 scales reflecting mental health were not correlated with any of the symptoms of CFS except for irritability and depression. CONCLUSION: Patients with CFS had marked impairment, in comparison with the general population and disease comparison groups. Moreover, the degree and pattern of impairment was different from that seen in patients with depression.Source
Am J Med. 1996 Sep;101(3):281-90. Link to article on publisher's siteDOI
10.1016/S0002-9343(96)00174-XPermanent Link to this Item
http://hdl.handle.net/20.500.14038/47393PubMed ID
8873490Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/S0002-9343(96)00174-X