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dc.contributor.authorPletcher, Mark J.
dc.contributor.authorVarosy, Paul
dc.contributor.authorKiefe, Catarina I.
dc.contributor.authorLewis, Cora E.
dc.contributor.authorSidney, Stephen
dc.contributor.authorHulley, Stephen B.
dc.date2022-08-11T08:10:41.000
dc.date.accessioned2022-08-23T17:16:40Z
dc.date.available2022-08-23T17:16:40Z
dc.date.issued2005-02-19
dc.date.submitted2010-04-27
dc.identifier.citationAm J Epidemiol. 2005 Mar 1;161(5):423-33. <a href="http://dx.doi.org/10.1093/aje/kwi062">Link to article on publisher's site</a>
dc.identifier.issn0002-9262 (Linking)
dc.identifier.doi10.1093/aje/kwi062
dc.identifier.pmid15718478
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47451
dc.description.abstractIt is unclear to what extent the apparently beneficial cardiovascular effects of moderate alcohol consumption are mediated by protection against atherosclerosis. Alcohol consumption, coronary heart disease risk factors, and coronary calcification (a marker of atherosclerosis) were measured during 15 years of follow-up in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (1985-2001). Among 3,037 participants aged 33-45 years after follow-up (55% women, 45% Black), the prevalence of coronary calcification was 8% for consumption of 0 drinks/week (n = 1,435), 9% for 1-6 drinks/week (n = 1,023), 13% for 7-13 drinks/week (n = 341), and 19% for > or = 14 drinks/week (n = 238) (p < 0.001 for trend). Calcification was also more common among binge drinkers (odds ratio = 2.1, 95% confidence interval: 1.6, 2.7). These associations persisted after adjustment for potential confounders (age, gender/ethnicity, income, physical activity, family history, body mass index, smoking) and intermediary factors (lipids, blood pressure, glucose, C-reactive protein, and fibrinogen). Stratification showed the dose-response relation most clearly in Black men; only heavier alcohol consumption (> or = 14 drinks/week) was associated with coronary calcification in other race/sex subgroups. These surprising findings suggest the presence of proatherogenic effects of alcohol in young adults, especially Black men, which may counterbalance high density lipoprotein cholesterol elevation and other possible benefits of alcohol consumption.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15718478&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1093/aje/kwi062
dc.subjectAdult
dc.subjectAfrican Continental Ancestry Group
dc.subjectAlcohol Drinking
dc.subjectAlcoholic Intoxication
dc.subjectCalcinosis
dc.subjectChi-Square Distribution
dc.subjectCoronary Artery Disease
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectLogistic Models
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrevalence
dc.subjectRisk Factors
dc.subjectBioinformatics
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleAlcohol consumption, binge drinking, and early coronary calcification: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) Study
dc.typeJournal Article
dc.source.journaltitleAmerican journal of epidemiology
dc.source.volume161
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/59
dc.identifier.contextkey1287804
html.description.abstract<p>It is unclear to what extent the apparently beneficial cardiovascular effects of moderate alcohol consumption are mediated by protection against atherosclerosis. Alcohol consumption, coronary heart disease risk factors, and coronary calcification (a marker of atherosclerosis) were measured during 15 years of follow-up in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (1985-2001). Among 3,037 participants aged 33-45 years after follow-up (55% women, 45% Black), the prevalence of coronary calcification was 8% for consumption of 0 drinks/week (n = 1,435), 9% for 1-6 drinks/week (n = 1,023), 13% for 7-13 drinks/week (n = 341), and 19% for > or = 14 drinks/week (n = 238) (p < 0.001 for trend). Calcification was also more common among binge drinkers (odds ratio = 2.1, 95% confidence interval: 1.6, 2.7). These associations persisted after adjustment for potential confounders (age, gender/ethnicity, income, physical activity, family history, body mass index, smoking) and intermediary factors (lipids, blood pressure, glucose, C-reactive protein, and fibrinogen). Stratification showed the dose-response relation most clearly in Black men; only heavier alcohol consumption (> or = 14 drinks/week) was associated with coronary calcification in other race/sex subgroups. These surprising findings suggest the presence of proatherogenic effects of alcohol in young adults, especially Black men, which may counterbalance high density lipoprotein cholesterol elevation and other possible benefits of alcohol consumption.</p>
dc.identifier.submissionpathqhs_pp/59
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages423-33


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