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    Burden of restless legs syndrome on health-related quality of life

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    Authors
    Kushida, Clete
    Martin, Marie
    Nikam, Prashant
    Blaisdell, Bonnie
    Wallenstein, Gene
    Ferini-Strambi, Luigi
    Ware, John E. Jr.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2007-02-03
    Keywords
    Adaptation, Psychological
    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Comorbidity
    *Cost of Illness
    Depression
    Female
    Health Status
    Humans
    Male
    Mental Health
    Middle Aged
    Quality of Life
    Restless Legs Syndrome
    *Sickness Impact Profile
    United States
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1007/s11136-006-9142-8
    Abstract
    OBJECTIVE: To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL). METHODS: The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples. RESULTS: All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes. CONCLUSION: After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.
    Source
    Qual Life Res. 2007 May;16(4):617-24. Epub 2007 Feb 1. Link to article on publisher's site
    DOI
    10.1007/s11136-006-9142-8
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47465
    PubMed ID
    17268935
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11136-006-9142-8
    Scopus Count
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    Population and Quantitative Health Sciences Publications

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