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dc.contributor.authorKushida, Clete
dc.contributor.authorMartin, Marie
dc.contributor.authorNikam, Prashant
dc.contributor.authorBlaisdell, Bonnie
dc.contributor.authorWallenstein, Gene
dc.contributor.authorFerini-Strambi, Luigi
dc.contributor.authorWare, John E. Jr.
dc.date2022-08-11T08:10:41.000
dc.date.accessioned2022-08-23T17:16:44Z
dc.date.available2022-08-23T17:16:44Z
dc.date.issued2007-02-03
dc.date.submitted2010-06-18
dc.identifier.citationQual Life Res. 2007 May;16(4):617-24. Epub 2007 Feb 1. <a href="http://dx.doi.org/10.1007/s11136-006-9142-8">Link to article on publisher's site</a>
dc.identifier.issn0962-9343 (Linking)
dc.identifier.doi10.1007/s11136-006-9142-8
dc.identifier.pmid17268935
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47465
dc.description.abstractOBJECTIVE: To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL). METHODS: The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples. RESULTS: All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes. CONCLUSION: After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17268935&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1007/s11136-006-9142-8
dc.subjectAdaptation, Psychological
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectComorbidity
dc.subject*Cost of Illness
dc.subjectDepression
dc.subjectFemale
dc.subjectHealth Status
dc.subjectHumans
dc.subjectMale
dc.subjectMental Health
dc.subjectMiddle Aged
dc.subjectQuality of Life
dc.subjectRestless Legs Syndrome
dc.subject*Sickness Impact Profile
dc.subjectUnited States
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleBurden of restless legs syndrome on health-related quality of life
dc.typeJournal Article
dc.source.journaltitleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
dc.source.volume16
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/602
dc.identifier.contextkey1363437
html.description.abstract<p>OBJECTIVE: To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL).</p> <p>METHODS: The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples.</p> <p>RESULTS: All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes.</p> <p>CONCLUSION: After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.</p>
dc.identifier.submissionpathqhs_pp/602
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages617-24


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