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    Comorbidity independently predicted death in older prostate cancer patients, more of whom died with than from their disease

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    Authors
    Fouad, Mona N.
    Mayo, Charlotte P.
    Funkhouser, Ellen M.
    Hall, H. Irene
    Urban, Donald A.
    Kiefe, Catarina I.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2004-09-11
    Keywords
    African Continental Ancestry Group
    Age Distribution
    Aged
    Aged, 80 and over
    Alabama
    Cardiovascular Diseases
    Cause of Death
    Comorbidity
    European Continental Ancestry Group
    Humans
    Male
    Neoplasms
    Prostatic Neoplasms
    Pulmonary Disease, Chronic Obstructive
    Retrospective Studies
    Severity of Illness Index
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    http://dx.doi.org/10.1016/j.jclinepi.2003.11.009
    Abstract
    OBJECTIVE: The purpose of this study was to examine the proportion of men who died from prostate cancer (PrCa) vs. with PrCa and assess the comorbid conditions associated with other-cause deaths. STUDY DESIGN AND SETTING: We identified all male decedents aged >/=65 years in Jefferson County, AL, in 1993-1995. By crosslinking three databases (death certificate, Medicare, and Veteran's Administration), we identified men whose deaths might have been caused by PrCa. We abstracted and reviewed medical records to rate comorbid conditions and determine whether or not death was due to PrCa. RESULTS: Of 561 men with a premortem diagnosis of PrCa, 42% died from PrCa and 53% died with PrCA; 50.2% of blacks died from PrCa vs. 36.9% of Whites. Other factors related to dying with PrCa included older age at death and a serious, or very serious, comorbid condition. Treatment did not have an independent effect on cause of death (i.e., death with vs. from PrCa). CONCLUSIONS: Comorbidity was an independent predictor of dying with PrCa, even after adjustment for ethnicity, age, and treatment. Given the as yet unproven benefit of PrCa screening, our results extend the body of information relevant to the screening decision; among men dying with a diagnosis of PrCa, only about 1/3 to 1/2 died from the disease.
    Source
    J Clin Epidemiol. 2004 Jul;57(7):721-9. Link to article on publisher's site
    DOI
    10.1016/j.jclinepi.2003.11.009
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47601
    PubMed ID
    15358400
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jclinepi.2003.11.009
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    Population and Quantitative Health Sciences Publications

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