Trends and outcomes associated with angiotensin-converting enzyme inhibitors
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Authors
Doubeni, Chyke A.Bigelow, Carol
Lessard, Darleen M.
Spencer, Frederick A.
Yarzebski, Jorge L.
Gore, Joel M.
Gurwitz, Jerry H.
Goldberg, Robert J.
UMass Chan Affiliations
Department of Family Medicine and Community HealthDepartment of Medicine, Division of Geriatric Medicine
Meyers Primary Care Institute
Department of Quantitative Health Sciences
Department of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2006-07-11Keywords
AgedAged, 80 and over
Angiotensin-Converting Enzyme Inhibitors
Drug Therapy
Female
Hospitalization
Humans
Male
Massachusetts
Middle Aged
Myocardial Infarction
Odds Ratio
Treatment Outcome
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
BACKGROUND: Limited recent data are available describing the patterns of use of angiotensin converting enzyme inhibitor (ACEI) therapy in patients with acute myocardial infarction (AMI), particularly from the more generalizable population-based setting. The purpose of this study was to examine trends in the receipt of ACEIs and associated short-term outcomes in patients hospitalized with AMI in a large Northeastern community. METHODS: We conducted a community-wide study of 7991 patients hospitalized with AMI in all metropolitan Worcester, Massachusetts, medical centers during 8 annual periods between 1990 and 2003. RESULTS: Among all patients, 44% received ACEI therapy during their acute hospitalization. There was a marked increase in the use of ACEIs between 1990 (23%) and 2003 (68%), particularly among those who were not on ACEIs before hospitalization. Patients who were previously on ACEIs were more likely to receive this therapy during hospitalization for AMI than were patients who were not previously on this therapy. Patients treated with ACEIs were significantly less likely to die (adjusted odds ratio [OR] 0.33; 95% confidence interval [CI] 0.27-0.41) during hospitalization than were patients who did not receive this therapy, with benefits observed across all subgroups examined. CONCLUSIONS: The results of this observational study demonstrate marked increases in the use of ACEIs in patients with AMI in the community setting and demonstrate the benefits to be gained from use of this therapy. Despite these encouraging trends, there remains room for more optimal use of this therapy.Source
Am J Med. 2006 Jul;119(7):616.e9-16. Link to article on publisher's siteDOI
10.1016/j.amjmed.2005.11.027Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47641PubMed ID
16828635Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.amjmed.2005.11.027