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dc.contributor.authorDoubeni, Chyke A.
dc.contributor.authorBigelow, Carol
dc.contributor.authorLessard, Darleen M.
dc.contributor.authorSpencer, Frederick A.
dc.contributor.authorYarzebski, Jorge L.
dc.contributor.authorGore, Joel M.
dc.contributor.authorGurwitz, Jerry H.
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:10:43.000
dc.date.accessioned2022-08-23T17:17:30Z
dc.date.available2022-08-23T17:17:30Z
dc.date.issued2006-07-11
dc.date.submitted2010-07-16
dc.identifier.citationAm J Med. 2006 Jul;119(7):616.e9-16. <a href="http://dx.doi.org/10.1016/j.amjmed.2005.11.027">Link to article on publisher's site</a>
dc.identifier.issn0002-9343 (Linking)
dc.identifier.doi10.1016/j.amjmed.2005.11.027
dc.identifier.pmid16828635
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47641
dc.description.abstractBACKGROUND: Limited recent data are available describing the patterns of use of angiotensin converting enzyme inhibitor (ACEI) therapy in patients with acute myocardial infarction (AMI), particularly from the more generalizable population-based setting. The purpose of this study was to examine trends in the receipt of ACEIs and associated short-term outcomes in patients hospitalized with AMI in a large Northeastern community. METHODS: We conducted a community-wide study of 7991 patients hospitalized with AMI in all metropolitan Worcester, Massachusetts, medical centers during 8 annual periods between 1990 and 2003. RESULTS: Among all patients, 44% received ACEI therapy during their acute hospitalization. There was a marked increase in the use of ACEIs between 1990 (23%) and 2003 (68%), particularly among those who were not on ACEIs before hospitalization. Patients who were previously on ACEIs were more likely to receive this therapy during hospitalization for AMI than were patients who were not previously on this therapy. Patients treated with ACEIs were significantly less likely to die (adjusted odds ratio [OR] 0.33; 95% confidence interval [CI] 0.27-0.41) during hospitalization than were patients who did not receive this therapy, with benefits observed across all subgroups examined. CONCLUSIONS: The results of this observational study demonstrate marked increases in the use of ACEIs in patients with AMI in the community setting and demonstrate the benefits to be gained from use of this therapy. Despite these encouraging trends, there remains room for more optimal use of this therapy.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16828635&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.amjmed.2005.11.027
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectDrug Therapy
dc.subjectFemale
dc.subjectHospitalization
dc.subjectHumans
dc.subjectMale
dc.subjectMassachusetts
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectOdds Ratio
dc.subjectTreatment Outcome
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleTrends and outcomes associated with angiotensin-converting enzyme inhibitors
dc.typeJournal Article
dc.source.journaltitleThe American journal of medicine
dc.source.volume119
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/768
dc.identifier.contextkey1397722
html.description.abstract<p>BACKGROUND: Limited recent data are available describing the patterns of use of angiotensin converting enzyme inhibitor (ACEI) therapy in patients with acute myocardial infarction (AMI), particularly from the more generalizable population-based setting. The purpose of this study was to examine trends in the receipt of ACEIs and associated short-term outcomes in patients hospitalized with AMI in a large Northeastern community.</p> <p>METHODS: We conducted a community-wide study of 7991 patients hospitalized with AMI in all metropolitan Worcester, Massachusetts, medical centers during 8 annual periods between 1990 and 2003.</p> <p>RESULTS: Among all patients, 44% received ACEI therapy during their acute hospitalization. There was a marked increase in the use of ACEIs between 1990 (23%) and 2003 (68%), particularly among those who were not on ACEIs before hospitalization. Patients who were previously on ACEIs were more likely to receive this therapy during hospitalization for AMI than were patients who were not previously on this therapy. Patients treated with ACEIs were significantly less likely to die (adjusted odds ratio [OR] 0.33; 95% confidence interval [CI] 0.27-0.41) during hospitalization than were patients who did not receive this therapy, with benefits observed across all subgroups examined.</p> <p>CONCLUSIONS: The results of this observational study demonstrate marked increases in the use of ACEIs in patients with AMI in the community setting and demonstrate the benefits to be gained from use of this therapy. Despite these encouraging trends, there remains room for more optimal use of this therapy.</p>
dc.identifier.submissionpathqhs_pp/768
dc.contributor.departmentDepartment of Family Medicine and Community Health
dc.contributor.departmentDepartment of Medicine, Division of Geriatric Medicine
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages616.e9-16


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