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    Medication errors with the use of allopurinol and colchicine: a retrospective study of a national, anonymous Internet-accessible error reporting system

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    Authors
    Mikuls, Ted R.
    Curtis, Jeffrey R.
    Allison, Jeroan J.
    Hicks, Rodney W.
    Saag, Kenneth G.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2006-02-17
    Keywords
    *Adverse Drug Reaction Reporting Systems
    Allopurinol
    Colchicine
    Gout
    Gout Suppressants
    Internet
    Medication Errors
    Retrospective Studies
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://www.jrheum.org/content/33/3/562.full.pdf+html
    Abstract
    OBJECTIVE: To more closely assess medication errors in gout care, we examined data from a national, Internet-accessible error reporting program over a 5-year reporting period. METHODS: We examined data from the MEDMARX database, covering the period from January 1, 1999 through December 31, 2003. For allopurinol and colchicine, we examined error severity, source, type, contributing factors, and healthcare personnel involved in errors, and we detailed errors resulting in patient harm. Causes of error and the frequency of other error characteristics were compared for gout medications versus other musculoskeletal treatments using the chi-square statistic. RESULTS: Gout medication errors occurred in 39% (n = 273) of facilities participating in the MEDMARX program. Reported errors were predominantly from the inpatient hospital setting and related to the use of allopurinol (n = 524), followed by colchicine (n = 315), probenecid (n = 50), and sulfinpyrazone (n = 2). Compared to errors involving other musculoskeletal treatments, allopurinol and colchicine errors were more often ascribed to problems with physician prescribing (7% for other therapies versus 23-39% for allopurinol and colchicine, p < 0.0001) and less often due to problems with drug administration or nursing error (50% vs 23-27%, p < 0.0001). CONCLUSION: Our results suggest that inappropriate prescribing practices are characteristic of errors occurring with the use of allopurinol and colchicine. Physician prescribing practices are a potential target for quality improvement interventions in gout care.
    Source
    J Rheumatol. 2006 Mar;33(3):562-6. Epub 2006 Feb 15.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47674
    PubMed ID
    16482645
    Related Resources
    Link to Article in PubMed
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    Population and Quantitative Health Sciences Publications

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