Vertebroplasty and kyphoplasty are associated with an increased risk of secondary vertebral compression fractures: a population-based cohort study
Authors
Mudano, Amy S.Bian, John
Cope, J. U.
Curtis, Jeffrey R.
Gross, T. P.
Allison, Jeroan J.
Kim, Y.
Briggs, D.
Elkins-Melton, Mary
Xi, J.
Saag, Kenneth G.
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2008-09-18Keywords
AgedAlabama
Cohort Studies
Female
Fractures, Compression
Humans
Kyphosis
Lumbar Vertebrae
Male
Middle Aged
Retrospective Studies
Risk Factors
Spinal Fractures
Thoracic Vertebrae
Treatment Outcome
Vertebroplasty
Bioinformatics
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
To better understand the risk of secondary vertebral compression fracture (VCF) following a vertebroplasty or kyphoplasty, we compared patients treated with those procedures to patients with a previous VCF. The risk of subsequent fracture was significantly greater among treatment patients, especially within 90 days of the procedure. INTRODUCTION: Predominantly uncontrolled studies suggest a greater risk of subsequent vertebral compression fractures (VCFs) associated with vertebroplasty/kyphoplasty. To further understand this risk, we conducted a population-based retrospective cohort study using data from a large regional health insurer. METHODS: Administrative claims procedure codes were used to identify patients receiving either a vertebroplasty or kyphoplasty (treatment group) and a comparison group of patients with a primary diagnosis of VCF who did not receive treatment during the same time period. The main outcomes of interest, validated by two independent medical record reviewers, were any new VCFs within (1) 90 days, (2) 360 days, and (3) at adjacent vertebral levels. Multivariable logistic regression examined the association of vertebroplasty/kyphoplasty with new VCFs. RESULTS: Among 48 treatment (51% vertebroplasty, 49% kyphoplasty) and 164 comparison patients, treated patients had a significantly greater risk of secondary VCFs than comparison patients for fractures within 90 days of the procedure or comparison group time point [adjusted odds ratio (OR) = 6.8; 95% confidence interval (CI) 1.7-26.9] and within 360 days (adjusted OR = 2.9; 95% CI 1.1-7.9). CONCLUSIONS: Patients who had undergone vertebroplasty/kyphoplasty had a greater risk of new VCFs compared to patients with prior VCFs who did not undergo either procedure.Source
Osteoporos Int. 2009 May;20(5):819-26. Epub 2008 Sep 17. Link to article on publisher's siteDOI
10.1007/s00198-008-0745-5Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47715PubMed ID
18797812Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s00198-008-0745-5