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    Do neighborhood socioeconomic deprivation and low social cohesion predict coronary calcification?: the CARDIA study

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    Authors
    Kim, Daniel
    Diez-Roux, Ana V.
    Kiefe, Catarina I.
    Kawachi, Ichiro
    Liu, Kiang
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2010-07-09
    Keywords
    Adolescent
    Adult
    Calcinosis
    Catchment Area (Health)
    Confidence Intervals
    Coronary Artery Disease
    Female
    Humans
    *Interpersonal Relations
    Male
    Middle Aged
    Predictive Value of Tests
    Prevalence
    Prospective Studies
    Research Design
    *Residence Characteristics
    Severity of Illness Index
    Socioeconomic Factors
    United States
    Young Adult
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1093/aje/kwq098
    Abstract
    Growing evidence suggests that neighborhood characteristics may influence the risk of coronary heart disease. No studies have yet explored associations of neighborhood attributes with subclinical atherosclerosis in younger adult populations. Using data on 2,974 adults (1,699 women, 1,275 men) aged 32-50 years in 2000 from the Coronary Artery Disease Risk Development in Young Adults (CARDIA) Study and 2000 US Census block-group-level data, the authors estimated multivariable-adjusted associations of neighborhood socioeconomic deprivation and perceived neighborhood cohesion with odds of coronary artery calcification (CAC) 5 years later. Among women, the quartiles of highest neighborhood deprivation and lowest cohesion were associated with higher odds of CAC after adjustment for individual-level demographic and socioeconomic factors (for deprivation, odds ratio = 2.49, 95% confidence interval: 1.22, 5.08 (P for trend = 0.03); for cohesion, odds ratio = 1.87, 95% confidence interval: 1.10, 3.16 (P for trend = 0.02)). Associations changed only slightly after adjustment for behavioral, psychosocial, and biologic factors. Among men, neither neighborhood deprivation nor cohesion was related to CAC. However, among men in deprived neighborhoods, low cohesion predicted higher CAC odds (for interaction between neighborhood deprivation and cohesion, P = 0.03). This study provides evidence on associations of neighborhood deprivation and cohesion with CAC in younger, asymptomatic adults. Neighborhood attributes may contribute to subclinical atherosclerosis.
    Source
    Am J Epidemiol. 2010 Aug 1;172(3):288-98. Epub 2010 Jul 7. Link to article on publisher's site
    DOI
    10.1093/aje/kwq098
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47765
    PubMed ID
    20610467
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/aje/kwq098
    Scopus Count
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    Population and Quantitative Health Sciences Publications

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