• Login
    View Item 
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Population and Quantitative Health Sciences
    • Population and Quantitative Health Sciences Publications
    • View Item
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Population and Quantitative Health Sciences
    • Population and Quantitative Health Sciences Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsProfilesView

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Kiel, Douglas P.
    Hannan, Marian T.
    Barton, Bruce A.
    Bouxsein, Mary L.
    Lang, Thomas F.
    Brown, Kathleen M.
    Shane, Elizabeth
    Magaziner, Jay
    Zimmerman, Sheryl
    Rubin, Clinton T.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2010-06-24
    Keywords
    Aged
    Aged, 80 and over
    Biological Markers
    Bone Density
    Calcium
    Dietary Supplements
    *Equipment and Supplies
    Female
    Humans
    Male
    Middle Aged
    Osteoporosis
    Patient Compliance
    Postural Balance
    Research Design
    Vibration
    Vitamin D
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1177/1740774510371014
    Abstract
    BACKGROUND: Osteoporosis is a common complication of aging. Alternatives to pharmacologic treatment are needed for older adults. Nonpharmacologic treatment with low magnitude, high frequency mechanical stimulation has been shown to prevent bone loss in animal and human studies. METHODS: The VIBES (Vibration to Improve Bone Density in Elderly Subjects) study is a randomized, double-blind, sham-controlled trial of the efficacy of low magnitude, high frequency mechanical stimulation in 200 men and women aged 60 years and older with bone mineral density T-scores by dual X-ray absorptiometry between -1 and -2.5 at entry. Participants are healthy, cognitively intact residents of independent living communities in the Boston area who receive free calcium and Vitamin D supplements. They are randomly assigned to active or sham treatment and stand on their assigned platform once daily for 10 min. All platforms have adherence data collection software downloadable to a laptop computer. Adverse events are closely monitored. 174 participants were randomized and will be followed for 2 years. Almost all active subjects have attained 1 year of follow-up. Bone mineral density is measured by both dual X-ray absorptiometry and quantitative computed tomography at baseline and annually. The main analysis will compare mean changes from baseline in volumetric bone density by quantitative computed tomography in active and sham groups. Adherence and treatment effect magnitude will also be evaluated. Secondary analyses will compare changes in two biochemical markers of bone turnover as well as longitudinal comparisons of muscle and balance endpoints. RESULTS: The VIBES trial has completed its first year of data collection and encountered multiple challenges leading to valuable lessons learned about the areas of recruitment from independent living communities, deployment of multiuser mechanical devices using radio frequency identification cards and electronic adherence monitoring, organization of transportation for imaging at a central site, and the expansion of study aims to include additional musculoskeletal outcomes. CONCLUSIONS: These lessons will guide future investigations in studies of individuals of advanced age.
    Source
    Clin Trials. 2010 Aug;7(4):354-67. Epub 2010 Jun 22. Link to article on publisher's site
    DOI
    10.1177/1740774510371014
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47832
    PubMed ID
    20571129
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1177/1740774510371014
    Scopus Count
    Collections
    Population and Quantitative Health Sciences Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Works found in eScholarship@UMassChan are protected by copyright unless otherwise indicated.
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.