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    The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression

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    Authors
    Elaimy, Ameer L.
    Amante, John J.
    Zhu, Lihua Julie
    Wang, Mengdie
    Walmsley, Charlotte
    Fitzgerald, Thomas J.
    Goel, Hira Lal
    Mercurio, Arthur M.
    UMass Chan Affiliations
    Department of Radiation Oncology
    Medical Scientist Training Program
    Department of Molecular, Cell and Cancer Biology
    Document Type
    Journal Article
    Publication Date
    2019-07-09
    Keywords
    DNA repair
    VEGF–neuropilin
    YAP/TAZ
    breast cancer
    Amino Acids, Peptides, and Proteins
    Cancer Biology
    Neoplasms
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628806/
    Abstract
    Vascular endothelial growth factor (VEGF) signaling in tumor cells mediated by neuropilins (NRPs) contributes to the aggressive nature of several cancers, including triple-negative breast cancer (TNBC), independently of its role in angiogenesis. Understanding the mechanisms by which VEGF-NRP signaling contributes to the phenotype of such cancers is a significant and timely problem. We report that VEGF-NRP2 promote homologous recombination (HR) in BRCA1 wild-type TNBC cells by contributing to the expression and function of Rad51, an essential enzyme in the HR pathway that mediates efficient DNA double-strand break repair. Mechanistically, we provide evidence that VEGF-NRP2 stimulates YAP/TAZ-dependent Rad51 expression and that Rad51 is a direct YAP/TAZ-TEAD transcriptional target. We also discovered that VEGF-NRP2-YAP/TAZ signaling contributes to the resistance of TNBC cells to cisplatin and that Rad51 rescues the defects in DNA repair upon inhibition of either VEGF-NRP2 or YAP/TAZ. These findings reveal roles for VEGF-NRP2 and YAP/TAZ in DNA repair, and they indicate a unified mechanism involving VEGF-NRP2, YAP/TAZ, and Rad51 that contributes to resistance to platinum chemotherapy.
    Source

    Elaimy AL, Amante JJ, Zhu LJ, Wang M, Walmsley CS, FitzGerald TJ, Goel HL, Mercurio AM. The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14174-14180. doi: 10.1073/pnas.1821194116. Epub 2019 Jun 24. PMID: 31235595; PMCID: PMC6628806. Link to article on publisher's site

    DOI
    10.1073/pnas.1821194116
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47911
    PubMed ID
    31235595
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1821194116
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