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    alpha(V)beta(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma

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    Authors
    Garlick, David S.
    Li, Jing
    Sansoucy, Brian
    Wang, Tao
    Griffith, Leeanne
    Fitzgerald, T. J.
    Butterfield, Julie
    Charbonneau, Bridget
    Violette, Shelia M.
    Weinreb, Paul H.
    Ratliff, Timothy L.
    Liao, Chun-Peng
    Roy-Burman, Pradip
    Vietri, Michele
    Lian, Jane B.
    Stein, Gary S.
    Altieri, Dario C.
    Languino, Lucia R.
    Show allShow less
    UMass Chan Affiliations
    Department of Radiation Oncology, Department of Cancer Biology, Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2012-04-10
    Keywords
    Neoplasms
    Oncology
    
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    Abstract
    Chronic inflammation is proposed to prime the development of prostate cancer. However, the mechanisms of prostate cancer initiation and development are not completely understood. The alpha(v)beta(6) integrin has been shown to play a role in epithelial development, wound healing and some epithelial cancers [1, 2]. Here, we investigate the expression of alpha(v)beta(6) in mouse models of prostatic inflammation and prostate cancer to establish a possible relationship between inflammation of the prostate, alpha(v)beta(6) expression and the progression of prostate cancer. Using immunohistochemical techniques, we show expression of alpha(v)beta(6) in two in vivo mouse models; the Pten(pc)-/- model containing a prostate- specific Pten tumor suppressor deletion that causes cancer, and the prostate ovalbumin-expressing transgenic (POET) inflammation mouse model. We show that the alpha(v)beta(6) integrin is induced in prostate cancer and inflammation in vivo in these two mouse models. alpha(v)beta(6) is expressed in all the mice with cancer in the Pten(pc-/-) model but not in age-matched wild-type mice. In the POET inflammation model, alpha(v)beta(6) is expressed in mice injected with activated T-cells, but in none of the control mice. In the POET model, we also used real time PCR to assess the expression of Transforming Growth Factor Beta 1 (TGFbeta1), a factor in inflammation that is activated by alpha(v)beta(6). In conclusion, through in vivo evidence, we conclude that alpha(v)beta(6) integrin may be a crucial link between prostatic inflammation and prostatic adenocarcinoma.
    Source
    Am J Transl Res. 2012;4(2):165-74. Epub 2012 Apr 10.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47926
    PubMed ID
    22611469
    Related Resources
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