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dc.contributor.authorKhanna, Geetika
dc.contributor.authorRosen, Nancy
dc.contributor.authorAnderson, James R.
dc.contributor.authorEhrlich, Peter F.
dc.contributor.authorDome, Jeffrey S.
dc.contributor.authorGow, Kenneth W.
dc.contributor.authorPerlman, Elizabeth
dc.contributor.authorBarnhart, Douglas
dc.contributor.authorKarolczuk, Kathryn
dc.contributor.authorGrundy, Paul
dc.date2022-08-11T08:10:45.000
dc.date.accessioned2022-08-23T17:18:48Z
dc.date.available2022-08-23T17:18:48Z
dc.date.issued2012-04-01
dc.date.submitted2014-01-25
dc.identifier.citationKhanna G, Rosen N, Anderson JR, Ehrlich PF, Dome JS, Gow KW, Perlman E, Barnhart D, Karolczuk K, Grundy P. Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2012 Apr;58(4):551-5. doi: 10.1002/pbc.23222. Epub 2011 Jun 14. PubMed PMID: 21674767; PubMed Central PMCID: PMC3175263. <a href="http://dx.doi.org/10.1002/pbc.23222">Link to article on publisher's site</a>
dc.identifier.issn1545-5009 (Linking)
dc.identifier.doi10.1002/pbc.23222
dc.identifier.pmid21674767
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47932
dc.description<p>This study was supported in part by Grant CA-29511 from the National Cancer Institute for the IROC Rhode Island (QARC), a quality assurance vehicle and data management service for diagnostic imaging and radiation oncology for the National Cancer Institute Clinical Trials Program. QARC is a research program within the University of Massachusetts Medical School led by Dr. Thomas (TJ) FitzGerald of the Department of Radiation Oncology.</p>
dc.description.abstractBACKGROUND: Pre-operative assessment of intravascular extension of Wilms tumor is essential to guide management. Our aim is to evaluate the diagnostic performance of multidetector CT in detection of tumor thrombus in Wilms tumor. PROCEDURE: The study population was drawn from the first 1,015 cases in the AREN03B2 study of the Children's Oncology Group. CT scans of children with (n = 62) and without (n = 111) tumor thrombus at nephrectomy were independently reviewed by two radiologists, blinded to patient information. Doppler sonography results were obtained from institutional radiology reports, as Doppler requires real-time evaluation. The diagnostic performance of CT and Doppler for detection of tumor thrombus was determined using nephrectomy findings as reference standard. RESULTS: In the primary nephrectomy group, tumor thrombus detection sensitivity, specificity of CT was 65.6, 84.8%, and Doppler was 45.8, 95.7%, respectively. In this group, sensitivity of CT, Doppler for detection of cavoatrial thrombus was 84.6 and 70.0%, respectively. In the secondary nephrectomy group, tumor thrombus detection sensitivity, specificity of CT was 86.7, 90.6%, and Doppler was 66.7, 100.0%, respectively. In this group, sensitivity of CT, Doppler for detection of cavoatrial thrombus was 96.0 and 68.8%, respectively. Pre-operative Doppler evaluation performed in 108/173 cases, detected 3 cases with intravenous extension (2 in renal vein, 1 in IVC at renal vein level) that were missed at CT. CONCLUSIONS: CT can accurately identify cavoatrial tumor thrombus that will impact surgical approach. Routine Doppler evaluation, after CT has already been performed, is not required in Wilms tumor.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21674767&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175263/
dc.subjectAdult
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectKidney Neoplasms
dc.subjectMale
dc.subjectMultidetector Computed Tomography
dc.subjectNephrectomy
dc.subjectRenal Veins
dc.subjectSensitivity and Specificity
dc.subjectThrombosis
dc.subjectUltrasonography, Doppler, Color
dc.subjectWilms Tumor
dc.subjectNeoplasms
dc.subjectOncology
dc.subjectRadiology
dc.titleEvaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group
dc.typeJournal Article
dc.source.journaltitlePediatric blood and cancer
dc.source.volume58
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiationoncology_pubs/37
dc.identifier.contextkey5020134
html.description.abstract<p>BACKGROUND: Pre-operative assessment of intravascular extension of Wilms tumor is essential to guide management. Our aim is to evaluate the diagnostic performance of multidetector CT in detection of tumor thrombus in Wilms tumor.</p> <p>PROCEDURE: The study population was drawn from the first 1,015 cases in the AREN03B2 study of the Children's Oncology Group. CT scans of children with (n = 62) and without (n = 111) tumor thrombus at nephrectomy were independently reviewed by two radiologists, blinded to patient information. Doppler sonography results were obtained from institutional radiology reports, as Doppler requires real-time evaluation. The diagnostic performance of CT and Doppler for detection of tumor thrombus was determined using nephrectomy findings as reference standard.</p> <p>RESULTS: In the primary nephrectomy group, tumor thrombus detection sensitivity, specificity of CT was 65.6, 84.8%, and Doppler was 45.8, 95.7%, respectively. In this group, sensitivity of CT, Doppler for detection of cavoatrial thrombus was 84.6 and 70.0%, respectively. In the secondary nephrectomy group, tumor thrombus detection sensitivity, specificity of CT was 86.7, 90.6%, and Doppler was 66.7, 100.0%, respectively. In this group, sensitivity of CT, Doppler for detection of cavoatrial thrombus was 96.0 and 68.8%, respectively. Pre-operative Doppler evaluation performed in 108/173 cases, detected 3 cases with intravenous extension (2 in renal vein, 1 in IVC at renal vein level) that were missed at CT.</p> <p>CONCLUSIONS: CT can accurately identify cavoatrial tumor thrombus that will impact surgical approach. Routine Doppler evaluation, after CT has already been performed, is not required in Wilms tumor.</p>
dc.identifier.submissionpathradiationoncology_pubs/37
dc.contributor.departmentQuality Assurance Review Center
dc.contributor.departmentDepartment of Radiation Oncology
dc.source.pages551-5


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