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    The Importance of Imaging in Radiation Oncology for National Clinical Trials Network Protocols

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    Authors
    Fitzgerald, Thomas J.
    Bishop-Jodoin, Maryann
    Laurie, Fran
    Ulin, Kenneth
    Moni, Janaki
    Cicchetti, Maria Giulia
    UMass Chan Affiliations
    Department of Radiation Oncology
    Quality Assurance Review Center
    Imaging and Radiation Oncology Core
    Document Type
    Journal Article
    Publication Date
    2018-11-15
    Keywords
    Neoplasms
    Oncology
    Radiation Medicine
    Radiology
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510266/
    Abstract
    Imaging is essential in successfully executing radiation therapy (RT) in oncology clinical trials. As technically sophisticated diagnostic imaging and RT were incorporated into trials, quality assurance in the National Clinical Trials Network groups entered a new era promoting image acquisition and review. Most trials involving RT require pre- and post-therapy imaging for target validation and outcome assessment. The increasing real-time (before and during therapy) imaging and RT object reviews are to ensure compliance with trial objectives. Objects easily transmit digitally for review from anywhere in the world. Physician interpretation of imaging and image application to RT treatment plans is essential for optimal trial execution. Imaging and RT data sets are used to credential RT sites to confirm investigator and institutional ability to meet trial target volume delineation and delivery requirements. Real-time imaging and RT object reviews can be performed multiple times during a trial to assess response to therapy and application of RT objects. This process has matured into an effective data management mechanism. When necessary, site and study investigators review objects together through web media technologies to ensure the patient is enrolled on the appropriate trial and the intended RT is planned and executed in a trial-compliant manner. Real-time imaging review makes sure: (1) the patient is entered and eligible for the trial, (2) the patient meets trial-specific adaptive therapy requirements, if applicable, and (3) the intended RT is according to trial guidelines. This review ensures the study population is uniform and the results are believable and can be applied to clinical practice.
    Source

    Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):775-782. doi: 10.1016/j.ijrobp.2018.08.039. Epub 2018 Oct 18. Link to article on publisher's site

    DOI
    10.1016/j.ijrobp.2018.08.039
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47982
    PubMed ID
    30353882
    Notes

    Full author list omitted for brevity. For the full list of authors, see article.

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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijrobp.2018.08.039
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