The Importance of Imaging in Radiation Oncology for National Clinical Trials Network Protocols
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Authors
Fitzgerald, Thomas J.Bishop-Jodoin, Maryann
Laurie, Fran
Ulin, Kenneth
Moni, Janaki
Cicchetti, Maria Giulia
UMass Chan Affiliations
Department of Radiation OncologyQuality Assurance Review Center
Imaging and Radiation Oncology Core
Document Type
Journal ArticlePublication Date
2018-11-15
Metadata
Show full item recordAbstract
Imaging is essential in successfully executing radiation therapy (RT) in oncology clinical trials. As technically sophisticated diagnostic imaging and RT were incorporated into trials, quality assurance in the National Clinical Trials Network groups entered a new era promoting image acquisition and review. Most trials involving RT require pre- and post-therapy imaging for target validation and outcome assessment. The increasing real-time (before and during therapy) imaging and RT object reviews are to ensure compliance with trial objectives. Objects easily transmit digitally for review from anywhere in the world. Physician interpretation of imaging and image application to RT treatment plans is essential for optimal trial execution. Imaging and RT data sets are used to credential RT sites to confirm investigator and institutional ability to meet trial target volume delineation and delivery requirements. Real-time imaging and RT object reviews can be performed multiple times during a trial to assess response to therapy and application of RT objects. This process has matured into an effective data management mechanism. When necessary, site and study investigators review objects together through web media technologies to ensure the patient is enrolled on the appropriate trial and the intended RT is planned and executed in a trial-compliant manner. Real-time imaging review makes sure: (1) the patient is entered and eligible for the trial, (2) the patient meets trial-specific adaptive therapy requirements, if applicable, and (3) the intended RT is according to trial guidelines. This review ensures the study population is uniform and the results are believable and can be applied to clinical practice.Source
Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):775-782. doi: 10.1016/j.ijrobp.2018.08.039. Epub 2018 Oct 18. Link to article on publisher's site
DOI
10.1016/j.ijrobp.2018.08.039Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47982PubMed ID
30353882Notes
Full author list omitted for brevity. For the full list of authors, see article.
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10.1016/j.ijrobp.2018.08.039