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    Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small ( < 2.5mm) cerebral vessels for aneurysm treatment: single institution experience

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    Authors
    Puri, Ajit S.
    Massari, Francesco
    Asai, Takumi
    Marosfoi, Miklos G.
    Kan, Peter
    Hou, Samuel Y.
    Howk, Mary
    Perras, Mary
    Brooks, Christopher
    Clarencon, Frederic
    Gounis, Matthew J.
    Wakhloo, Ajay K.
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    UMass Chan Affiliations
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2015-12-23
    Keywords
    Flow diversion
    Flow diverter stents
    Intracranial aneurysm
    Pipeline™ Embolization Device
    Small arteries
    Cardiovascular Diseases
    Nervous System Diseases
    Neurology
    Radiology
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1007/s00234-015-1630-5
    Abstract
    INTRODUCTION: Flow diversion is being increasingly used to treat cerebral aneurysms. We present our experience using these stents to treat aneurysms distal to the circle of Willis with parent arteries smaller than 2.5 mm. METHODS: Aneurysms treated with a Pipeline Embolization Device in vessels less than 2.5 mm between June 2012 and August 2014 were included. We evaluated risk factors, family history of aneurysms, aneurysm characteristics, National Institute of Health Stroke Scale (NIHSS), and modified Rankin scale (mRS) on admission and angiography and clinical outcome at discharge, 6 months, and 1 year. RESULTS: We included seven patients with a mean age of 65 years. The parent vessel size ranged from 1.5 to 2.3 mm; mean 1.9 mm. Location of the aneurysms was as follows: two aneurysms centered along the pericallosal artery (one left, one right), one on the right angular artery, one aneurysm at the anterior communicating artery (ACom), one at the ACom-right A2 anterior cerebral artery (ACA), one at the lenticulostriate artery, and one at the A1-A2 ACA artery. Aneurysms ranged from 1 to 12 mm in diameter. All aneurysms were treated with a single Pipeline Embolization Device (PED). No peri- or post-procedural complications or mortality occurred. The patients were discharged with no change in NIHSS or mRS score. Angiographic follow-up was available in six patients. Angiography showed complete aneurysm occlusion in all. NIHSS and mRS remained unchanged at follow-up. CONCLUSION: Our preliminary results show that flow diversion technology is an effective and safe therapy for aneurysms located on small cerebral arteries. Larger studies with long-term follow-up are needed to validate our promising results.
    Source
    Neuroradiology. 2015 Dec 23. Link to article on publisher's site
    DOI
    10.1007/s00234-015-1630-5
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48041
    PubMed ID
    26700827
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00234-015-1630-5
    Scopus Count
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    Radiology Publications

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