Authors
Shin, NaomiKim, Young H.
Xu, Hao
Shi, Hai-Bin
Zhang, Qing-Qiao
Colon Pons, Jean Paul
Kim, Ducksoo
Xu, Yi
Wu, Fei-Yun
Han, Samuel
Lee, Byung-Boong
Li, Lin-Sun
UMass Chan Affiliations
Senior Scholars ProgramSchool of Medicine
Department of Gastroenterology
Department of Radiology
Document Type
Journal ArticlePublication Date
2016-06-08Keywords
Budd-ChiariHepatic vein outflow tract obstruction
Hepatic vein thrombosis
Membranous obstruction of the inferior vena cava
Obliterative hepatocavopathy
Digestive System Diseases
Hepatology
Radiology
Metadata
Show full item recordAbstract
AIM: To re-examine whether hepatic vein thrombosis (HVT) (classical Budd-Chiari syndrome) and hepatic vena cava-Budd Chiari syndrome (HVC-BCS) are the same disorder. METHODS: A systematic review of observational studies conducted in adult subjects with primary BCS, hepatic vein outflow tract obstruction, membranous obstruction of the inferior vena cava (IVC), obliterative hepatocavopathy, or HVT during the period of January 2000 until February 2015 was conducted using the following databases: Cochrane Library, CINAHL, MEDLINE, PubMed and Scopus. RESULTS: Of 1299 articles identified, 26 were included in this study. Classical BCS is more common in women with a pure hepatic vein obstruction (49%-74%). HVC-BCS is more common in men with the obstruction often located in both the inferior vena cava and hepatic veins (14%-84%). Classical BCS presents with acute abdominal pain, ascites, and hepatomegaly. HVC-BCS presents with chronic abdominal pain and abdominal wall varices. Myeloproliferative neoplasms (MPN) are the most common etiology of classical BCS (16%-62%) with the JAK2V617-F mutation found in 26%-52%. In HVC-BCS, MPN are found in 4%-5%, and the JAK2V617-F mutation in 2%-5%. Classical BCS responds well to medical management alone and 1(st) line management of HVC-BCS involves percutaneous recanalization, with few managed with medical management alone. CONCLUSION: Systematic review of recent data suggests that classical BCS and HVC-BCS may be two clinically different disorders that involve the disruption of hepatic venous outflow.Source
World J Hepatol. 2016 Jun 8;8(16):691-702. doi: 10.4254/wjh.v8.i16.691. Link to article on publisher's siteDOI
10.4254/wjh.v8.i16.691Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48057PubMed ID
27326316Notes
Naomi Shin participated in this study as a medical student in the Senior Scholars research program at the University of Massachusetts Medical School.
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Link to Article in PubMedRights
Copyright ©The Author(s) 2016.Distribution License
http://creativecommons.org/licenses/by-nc/4.0/ae974a485f413a2113503eed53cd6c53
10.4254/wjh.v8.i16.691