Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome
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Document Type
Journal ArticlePublication Date
2016-11-01Keywords
AcneCRMO
Hyperostosis
Osteitis
Palmoplantar pustulosis
SAPHO syndrome
Vertebral corner lesion
‘Bull's head’ sign
Dermatology
Radiology
Rheumatology
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Show full item recordAbstract
Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region classically yields a 'bull's head' pattern of radionuclide uptake. Magnetic resonance imaging (MRI) can demonstrate corner lesions of vertebral bodies. Ultrasound often reveals peripheral enthesitis. Late radiographic features are usually osteoproliferative. PET/CT can identify chronic lesions. Differential diagnostic considerations include osteomyelitis and malignancy, which often prompt bone biopsy.Source
Rheum Dis Clin North Am. 2016 Nov;42(4):695-710. doi: 10.1016/j.rdc.2016.07.011. Link to article on publisher's siteDOI
10.1016/j.rdc.2016.07.011Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48110PubMed ID
27742022Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.rdc.2016.07.011