We are upgrading the repository! A content freeze is in effect until December 6, 2024. New submissions or changes to existing items will not be allowed during this period. All content already published will remain publicly available for searching and downloading. Updates will be posted in the Website Upgrade 2024 FAQ in the sidebar Help menu. Reach out to escholarship@umassmed.edu with any questions.
The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease
UMass Chan Affiliations
Department of RadiologyDocument Type
Journal ArticlePublication Date
2012-07-01
Metadata
Show full item recordAbstract
BACKGROUND: The currently available mechanical devices fail to achieve recanalization in as many as 20-40% of proximal arterial occlusion strokes. OBJECTIVE: The preclinical evaluation of the safety and efficacy of a novel thrombectomy device designed to achieve immediate flow restoration by quickly removing clot is reported. METHODS: Four confirmatory animal studies were performed with the Trevo device (Concentric Medical Inc, Mountain View, California, USA) in the swine (n=2) and canine (n=1) models of arterial thrombo-occlusive disease employing autologous thrombin generated thrombi. The angiographic response and the degree of device-clot incorporation were evaluated. High resolution flat panel three-dimensional CT was performed to further define the in vivo device-thrombus-vessel interaction. Finally, samples of three swine vessels treated with six passes of the device were explanted for histopathological analysis. RESULTS: A total of 16 clots of variable hardness and consistency were implanted in a variety of vascular settings, including the swine internal maxillary, lingual and forelimb arteries as well as the canine external carotid and vertebral arteries. Thrombolysis in Myocardial Infarction (TIMI) 2-3 reperfusion was achieved in all cases immediately after device deployment. All 16 clots were retrieved after one (n=15) or two (n=1) passes with the device. Histopathological analysis demonstrated severe disruption of the intima but no hemorrhage of media or adventitia. CONCLUSION: The experimental data suggest that the Trevo device is highly effective at achieving immediate reperfusion of occluded arteries without causing any clinically significant disruption of vascular integrity.Source
J Neurointerv Surg. 2012 Jul;4(4):295-300. Epub 2011 Aug 20. Link to article on publisher's siteDOI
10.1136/neurintsurg-2011-010053Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48182PubMed ID
21990512Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1136/neurintsurg-2011-010053