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dc.contributor.authorNogueira, Raul G.
dc.contributor.authorLevy, Elad I.
dc.contributor.authorGounis, Matthew J.
dc.contributor.authorSiddiqui, Adnan H.
dc.date2022-08-11T08:10:47.000
dc.date.accessioned2022-08-23T17:19:54Z
dc.date.available2022-08-23T17:19:54Z
dc.date.issued2012-07-01
dc.date.submitted2017-06-19
dc.identifier.citationJ Neurointerv Surg. 2012 Jul;4(4):295-300. Epub 2011 Aug 20. <a href="https://doi.org/10.1136/neurintsurg-2011-010053">Link to article on publisher's site</a>
dc.identifier.issn1759-8478 (Linking)
dc.identifier.doi10.1136/neurintsurg-2011-010053
dc.identifier.pmid21990512
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48182
dc.description.abstractBACKGROUND: The currently available mechanical devices fail to achieve recanalization in as many as 20-40% of proximal arterial occlusion strokes. OBJECTIVE: The preclinical evaluation of the safety and efficacy of a novel thrombectomy device designed to achieve immediate flow restoration by quickly removing clot is reported. METHODS: Four confirmatory animal studies were performed with the Trevo device (Concentric Medical Inc, Mountain View, California, USA) in the swine (n=2) and canine (n=1) models of arterial thrombo-occlusive disease employing autologous thrombin generated thrombi. The angiographic response and the degree of device-clot incorporation were evaluated. High resolution flat panel three-dimensional CT was performed to further define the in vivo device-thrombus-vessel interaction. Finally, samples of three swine vessels treated with six passes of the device were explanted for histopathological analysis. RESULTS: A total of 16 clots of variable hardness and consistency were implanted in a variety of vascular settings, including the swine internal maxillary, lingual and forelimb arteries as well as the canine external carotid and vertebral arteries. Thrombolysis in Myocardial Infarction (TIMI) 2-3 reperfusion was achieved in all cases immediately after device deployment. All 16 clots were retrieved after one (n=15) or two (n=1) passes with the device. Histopathological analysis demonstrated severe disruption of the intima but no hemorrhage of media or adventitia. CONCLUSION: The experimental data suggest that the Trevo device is highly effective at achieving immediate reperfusion of occluded arteries without causing any clinically significant disruption of vascular integrity.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21990512&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1136/neurintsurg-2011-010053
dc.subjectNeurology
dc.subjectRadiology
dc.subjectSurgery
dc.titleThe Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease
dc.typeJournal Article
dc.source.journaltitleJournal of neurointerventional surgery
dc.source.volume4
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/299
dc.identifier.contextkey10320039
html.description.abstract<p>BACKGROUND: The currently available mechanical devices fail to achieve recanalization in as many as 20-40% of proximal arterial occlusion strokes.</p> <p>OBJECTIVE: The preclinical evaluation of the safety and efficacy of a novel thrombectomy device designed to achieve immediate flow restoration by quickly removing clot is reported.</p> <p>METHODS: Four confirmatory animal studies were performed with the Trevo device (Concentric Medical Inc, Mountain View, California, USA) in the swine (n=2) and canine (n=1) models of arterial thrombo-occlusive disease employing autologous thrombin generated thrombi. The angiographic response and the degree of device-clot incorporation were evaluated. High resolution flat panel three-dimensional CT was performed to further define the in vivo device-thrombus-vessel interaction. Finally, samples of three swine vessels treated with six passes of the device were explanted for histopathological analysis. RESULTS: A total of 16 clots of variable hardness and consistency were implanted in a variety of vascular settings, including the swine internal maxillary, lingual and forelimb arteries as well as the canine external carotid and vertebral arteries. Thrombolysis in Myocardial Infarction (TIMI) 2-3 reperfusion was achieved in all cases immediately after device deployment. All 16 clots were retrieved after one (n=15) or two (n=1) passes with the device. Histopathological analysis demonstrated severe disruption of the intima but no hemorrhage of media or adventitia.</p> <p>CONCLUSION: The experimental data suggest that the Trevo device is highly effective at achieving immediate reperfusion of occluded arteries without causing any clinically significant disruption of vascular integrity.</p>
dc.identifier.submissionpathradiology_pubs/299
dc.contributor.departmentDepartment of Radiology
dc.source.pages295-300


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