Show simple item record

dc.contributor.authorReichstetter, Sandra
dc.contributor.authorCastillo, Gerardo M.
dc.contributor.authorLai, ManShun
dc.contributor.authorNishimoto-Ashfield, Akiko
dc.contributor.authorBanerjee, Aryamitra
dc.contributor.authorBogdanov, Alexei A. Jr.
dc.contributor.authorLyubimov, Alexander V.
dc.contributor.authorBolotin, Elijah M.
dc.date2022-08-11T08:10:47.000
dc.date.accessioned2022-08-23T17:19:55Z
dc.date.available2022-08-23T17:19:55Z
dc.date.issued2012-04-01
dc.date.submitted2017-06-19
dc.identifier.citationPharm Res. 2012 Apr;29(4):1033-9. Epub 2011 Dec 28. <a href="https://doi.org/10.1007/s11095-011-0646-8">Link to article on publisher's site</a>
dc.identifier.issn0724-8741 (Linking)
dc.identifier.doi10.1007/s11095-011-0646-8
dc.identifier.pmid22203325
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48187
dc.description.abstractPURPOSE: To develop a long-acting formulation of native human insulin with a similar pharmacodynamics (PD) profile as the insulin analogue insulin glargine (Lantus(R), Sanofi-Aventis) with the expectation of retaining native human insulin's superior safety profile as insulin glargine is able to activate the insulin-like growth factor 1 (IGF-1) receptor and is linked to a number of malignancies at a higher rate than regular human insulin. METHODS: Development of protected graft copolymer (PGC) excipients that bind native human insulin non-covalently and testing blood glucose control obtained with these formulations in streptozotocin-induced diabetic Sprague Dawley rats compared to equally dosed insulin glargine. RESULTS: PGC-formulations of native human insulin are able to control blood glucose to the same extent and for the same amount of time after s.c. injection as the insulin analogue insulin glargine. No biochemical changes were made to the insulin that would change receptor binding and activation with their possible negative effects on the safety of the insulin. CONCLUSION: Formulation with the PGC excipient offers a viable alternative to biochemically changing insulin or other receptor binding peptides to improve PD properties.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22203325&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1007/s11095-011-0646-8
dc.subjectPharmacy and Pharmaceutical Sciences
dc.subjectRadiology
dc.titleProtected graft copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus(R) (insulin-glargine): a streptozotocin-induced, diabetic Sprague Dawley rats study
dc.typeJournal Article
dc.source.journaltitlePharmaceutical research
dc.source.volume29
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/302
dc.identifier.contextkey10320042
html.description.abstract<p>PURPOSE: To develop a long-acting formulation of native human insulin with a similar pharmacodynamics (PD) profile as the insulin analogue insulin glargine (Lantus(R), Sanofi-Aventis) with the expectation of retaining native human insulin's superior safety profile as insulin glargine is able to activate the insulin-like growth factor 1 (IGF-1) receptor and is linked to a number of malignancies at a higher rate than regular human insulin.</p> <p>METHODS: Development of protected graft copolymer (PGC) excipients that bind native human insulin non-covalently and testing blood glucose control obtained with these formulations in streptozotocin-induced diabetic Sprague Dawley rats compared to equally dosed insulin glargine.</p> <p>RESULTS: PGC-formulations of native human insulin are able to control blood glucose to the same extent and for the same amount of time after s.c. injection as the insulin analogue insulin glargine. No biochemical changes were made to the insulin that would change receptor binding and activation with their possible negative effects on the safety of the insulin.</p> <p>CONCLUSION: Formulation with the PGC excipient offers a viable alternative to biochemically changing insulin or other receptor binding peptides to improve PD properties.</p>
dc.identifier.submissionpathradiology_pubs/302
dc.contributor.departmentDepartment of Radiology
dc.source.pages1033-9


This item appears in the following Collection(s)

Show simple item record