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    Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke

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    Authors
    van der Bom, Imramsjah M. J.
    Mehra, Manik
    Walvick, Ronn P.
    Chueh, Juyu
    Gounis, Matthew J.
    UMass Chan Affiliations
    New England Center for Stroke Research
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2012-02-01
    Keywords
    Neurology
    Radiology
    
    Metadata
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    Link to Full Text
    https://doi.org/10.3174/ajnr.A2944
    Abstract
    BACKGROUND AND PURPOSE: Previous studies have shown the feasibility of assessing qualitative CBV measurements in the angiography suite by using FPD-CBCT systems. We have investigated the correlation of FPD-CBCT CBV lesion volumes to the infarct volume. MATERIALS AND METHODS: Unilateral strokes were created in 7 adult dogs. MR imaging and FPD-CBCT data were obtained after MCA occlusion. FPD-CBCT CBV and ADC maps were generated for all subjects. The animals were sacrificed immediately following the last imaging study to measure infarct volume on histology. The reliability of FPD-CBCT-based lesion volume measurements was compared with those measured histologically by using regression and Bland-Altman analysis. RESULTS: The best correlation (R(2) = 0.72) between lesion volumes assessed with FPD-CBCT and histology was established with a threshold of mean healthy CBV - 2.5 x SD. These results were inferior to the correlation of lesion volumes measured with ADC and histology (R(2) = 0.99). Bland-Altman analysis showed that the agreement of ADC-derived lesion volumes with histology was superior to the agreement of FPD-CBCT-derived lesion volumes with histology. CONCLUSIONS: We correlated FPD-CBCT measurements of CBV and MR ADC lesion volumes with histologically assessed infarct volume. As expected, ADC is a very accurate and precise method for determining the extent of infarction. FPD-CBCT CBV lesion volumes are correlated to the size of the infarct. Improvement of FPD-CBCT image quality provides an opportunity to establish quantitative CBV measurement in the angiography suite.
    Source
    AJNR Am J Neuroradiol. 2012 Feb;33(2):353-8. Epub 2011 Dec 15. Link to article on publisher's site
    DOI
    10.3174/ajnr.A2944
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48192
    PubMed ID
    22173756
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.3174/ajnr.A2944
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