In vitro activity of a novel compound, Mul-1867, against clinically significant fungi Candida spp. and Aspergillus spp
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UMass Chan Affiliations
Department of RadiologyDocument Type
Journal ArticlePublication Date
2017-07-01Keywords
BiofilmCystic fibrosis
Fungi
Immunocompromised
Pulmonary infection
Resistant
Bacterial Infections and Mycoses
Chemicals and Drugs
Radiology
Respiratory Tract Diseases
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There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as well as resistant clinical isolates, with minimum fungicidal concentrations (MFCs) varying from 0.06 microg/mL to 0.5 microg/mL. It was also highly effective against pre-formed 48-h-old biofilms formed by yeasts and moulds. The half-minimal biofilm eradication concentration (MBEC50) was equal to the MFC. The minimum biofilm eradication concentration to eliminate 90% of biofilms (MBEC90) varied from 1 x to 4 x MFC. Scanning electron microscopy revealed morphological changes accompanied by the release of intracellular material from the fungal cells following exposure to Mul-1867. Furthermore, an increased concentration of nucleic acids was found in the medium after 5 min and 20 min of Mul-1867 treatment, indicating leakage of cytoplasmic contents. Overall, these data indicate that Mul-1867 may be a promising inhaled antifungal agent for the treatment and prevention of fungal respiratory infections.Source
Int J Antimicrob Agents. 2017 Jul;50(1):47-54. 10.1016/j.ijantimicag.2017.02.011. Epub 2017 Apr 27. Link to article on publisher's siteDOI
10.1016/j.ijantimicag.2017.02.011Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48212PubMed ID
28457835Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ijantimicag.2017.02.011