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    In vitro activity of a novel compound, Mul-1867, against clinically significant fungi Candida spp. and Aspergillus spp

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    Authors
    Tetz, George
    Cynamon, Michael
    Hendricks, Gregory M.
    Vikina, Daria
    Tetz, Victor
    UMass Chan Affiliations
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2017-07-01
    Keywords
    Biofilm
    Cystic fibrosis
    Fungi
    Immunocompromised
    Pulmonary infection
    Resistant
    Bacterial Infections and Mycoses
    Chemicals and Drugs
    Radiology
    Respiratory Tract Diseases
    
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    https://doi.org/10.1016/j.ijantimicag.2017.02.011
    Abstract
    There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as well as resistant clinical isolates, with minimum fungicidal concentrations (MFCs) varying from 0.06 microg/mL to 0.5 microg/mL. It was also highly effective against pre-formed 48-h-old biofilms formed by yeasts and moulds. The half-minimal biofilm eradication concentration (MBEC50) was equal to the MFC. The minimum biofilm eradication concentration to eliminate 90% of biofilms (MBEC90) varied from 1 x to 4 x MFC. Scanning electron microscopy revealed morphological changes accompanied by the release of intracellular material from the fungal cells following exposure to Mul-1867. Furthermore, an increased concentration of nucleic acids was found in the medium after 5 min and 20 min of Mul-1867 treatment, indicating leakage of cytoplasmic contents. Overall, these data indicate that Mul-1867 may be a promising inhaled antifungal agent for the treatment and prevention of fungal respiratory infections.
    Source
    Int J Antimicrob Agents. 2017 Jul;50(1):47-54. 10.1016/j.ijantimicag.2017.02.011. Epub 2017 Apr 27. Link to article on publisher's site
    DOI
    10.1016/j.ijantimicag.2017.02.011
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48212
    PubMed ID
    28457835
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijantimicag.2017.02.011
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