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dc.contributor.authorChueh, Juyu
dc.contributor.authorvan der Marel, Kajo
dc.contributor.authorGounis, Matthew J.
dc.contributor.authorKing, Robert M.
dc.contributor.authorZheng, Shaokuan
dc.contributor.authorBrooks, Olivia W.
dc.contributor.authorRappleye, Jeff W.
dc.date2022-08-11T08:10:47.000
dc.date.accessioned2022-08-23T17:20:04Z
dc.date.available2022-08-23T17:20:04Z
dc.date.issued2017-03-09
dc.date.submitted2017-08-07
dc.identifier.citationJ Neurointerv Surg. 2017 Mar 9. pii: neurintsurg-2016-012974. 10.1136/neurintsurg-2016-012974. <a href="https://doi.org/10.1136/neurintsurg-2016-012974">Link to article on publisher's site</a>
dc.identifier.issn1759-8478 (Linking)
dc.identifier.doi10.1136/neurintsurg-2016-012974
dc.identifier.pmid28280114
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48221
dc.description.abstractBACKGROUND AND PURPOSE: Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD. MATERIALS AND METHODS: A patient specific injection mold was 3D printed to construct a geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel was infused into the core shell mold to form the stenotic artery. The ICAD phantom incorporated materials mimicking a stenotic vessel and plaque components, including fibrous cap and lipid core. Two phantoms were scanned using high resolution cone beam CT and compared with four different 3 T MRI systems across eight different sites over a period of 18 months. Inter-phantom variability was assessed by lumen dimensions and contrast to noise ratio (CNR). RESULTS: Quantitative evaluation of the minimum lumen radius in the stenosis showed that the radius was on average 0.80 mm (95% CI 0.77 to 0.82 mm) in model 1 and 0.77 mm (95% CI 0.74 to 0.81 mm) in model 2. The highest CNRs were observed for comparisons between lipid and vessel wall. To evaluate manufacturing reproducibility, the CNR variability between the two models had an average absolute difference of 4.31 (95% CI 3.82 to 5.78). Variation in CNR between the images from the same scanner separated by 7 months was 2.5-6.2, showing reproducible phantom durability. CONCLUSIONS: A plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multicenter high resolution MRI standardization.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28280114&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1136/neurintsurg-2016-012974
dc.subjectAtherosclerosis
dc.subjectMRI
dc.subjectStenosis
dc.subjectVessel Wall
dc.subjectNeurology
dc.subjectRadiology
dc.subjectSurgery
dc.titleDevelopment of a high resolution MRI intracranial atherosclerosis imaging phantom
dc.typeJournal Article
dc.source.journaltitleJournal of neurointerventional surgery
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/336
dc.identifier.contextkey10555100
html.description.abstract<p>BACKGROUND AND PURPOSE: Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD.</p> <p>MATERIALS AND METHODS: A patient specific injection mold was 3D printed to construct a geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel was infused into the core shell mold to form the stenotic artery. The ICAD phantom incorporated materials mimicking a stenotic vessel and plaque components, including fibrous cap and lipid core. Two phantoms were scanned using high resolution cone beam CT and compared with four different 3 T MRI systems across eight different sites over a period of 18 months. Inter-phantom variability was assessed by lumen dimensions and contrast to noise ratio (CNR).</p> <p>RESULTS: Quantitative evaluation of the minimum lumen radius in the stenosis showed that the radius was on average 0.80 mm (95% CI 0.77 to 0.82 mm) in model 1 and 0.77 mm (95% CI 0.74 to 0.81 mm) in model 2. The highest CNRs were observed for comparisons between lipid and vessel wall. To evaluate manufacturing reproducibility, the CNR variability between the two models had an average absolute difference of 4.31 (95% CI 3.82 to 5.78). Variation in CNR between the images from the same scanner separated by 7 months was 2.5-6.2, showing reproducible phantom durability.</p> <p>CONCLUSIONS: A plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multicenter high resolution MRI standardization.</p>
dc.identifier.submissionpathradiology_pubs/336
dc.contributor.departmentNew England Center for Stroke Research
dc.contributor.departmentDepartment of Radiology


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