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Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study

dc.contributor.authorAquarius, Rene
dc.contributor.authorSmits, Debby
dc.contributor.authorGounis, Matthew J
dc.contributor.authorLeenders, William P.
dc.contributor.authorde Vries, Joost
dc.date2022-08-11T08:10:47.000
dc.date.accessioned2022-08-23T17:20:05Z
dc.date.available2022-08-23T17:20:05Z
dc.date.issued2017-02-08
dc.date.submitted2017-08-07
dc.identifier.citationJ Neurointerv Surg. 2017 Feb 8. pii: neurintsurg-2016-012878. 10.1136/neurintsurg-2016-012878. <a href="https://doi.org/10.1136/neurintsurg-2016-012878">Link to article on publisher's site</a>
dc.identifier.issn1759-8478 (Linking)
dc.identifier.doi10.1136/neurintsurg-2016-012878
dc.identifier.pmid28179543
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48224
dc.description.abstractBACKGROUND: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model. METHODS: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted. RESULTS: After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent. CONCLUSIONS: This model can be used to test the effects of FDs in future studies.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28179543&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1136/neurintsurg-2016-012878
dc.subjectAneurysm
dc.subjectArtery
dc.subjectFlow Diverter
dc.subjectTechnique
dc.subjectNeurology
dc.subjectRadiology
dc.subjectSurgery
dc.titleFlow diverter implantation in a rat model of sidewall aneurysm: a feasibility study
dc.typeJournal Article
dc.source.journaltitleJournal of neurointerventional surgery
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/339
dc.identifier.contextkey10555106
html.description.abstract<p>BACKGROUND: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.</p> <p>METHODS: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted.</p> <p>RESULTS: After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent.</p> <p>CONCLUSIONS: This model can be used to test the effects of FDs in future studies.</p>
dc.identifier.submissionpathradiology_pubs/339
dc.contributor.departmentRadiology


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