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dc.contributor.authorKing, Robert M.
dc.contributor.authorBrooks, Olivia W.
dc.contributor.authorLangan, Erin T.
dc.contributor.authorCaroff, Jildaz
dc.contributor.authorClarencon, Frederic
dc.contributor.authorTamura, Takamitsu
dc.contributor.authorWainwright, John Michael
dc.contributor.authorGounis, Matthew J.
dc.contributor.authorMarosfoi, Miklos G.
dc.contributor.authorPuri, Ajit S.
dc.date2022-08-11T08:10:47.000
dc.date.accessioned2022-08-23T17:20:12Z
dc.date.available2022-08-23T17:20:12Z
dc.date.issued2017-11-10
dc.date.submitted2018-01-03
dc.identifier.citationJ Neurointerv Surg. 2017 Nov 10. pii: neurintsurg-2017-013502. doi: 10.1136/neurintsurg-2017-013502. [Epub ahead of print] <a href="https://doi.org/10.1136/neurintsurg-2017-013502">Link to article on publisher's site</a>
dc.identifier.issn1759-8478 (Linking)
dc.identifier.doi10.1136/neurintsurg-2017-013502
dc.identifier.pmid29127197
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48249
dc.description.abstractBACKGROUND: Optical coherence tomography (OCT) is a high resolution intravascular imaging method that allows visualization of flow diverter struts and the vessel wall. In this study, malapposition of the flow diverter that continues into the neck of the aneurysm, named communicating malapposition (CM), was investigated as a potential factor for delayed aneurysm healing. METHODS: 40 New Zealand White rabbits underwent elastase induced aneurysm creation, and were subsequently assigned to one of four treatment groups based on flow diverter type and administration of antiplatelet therapy. All animals underwent post device deployment balloon angioplasty and subsequent OCT to assess device/vessel apposition. The incidence of CM seen on OCT was assessed with a binary scoring system: 0-CM present; 1-CM absent. At 30 days, DSA was acquired to assess aneurysm healing. Aneurysm healing on terminal DSA was measured using a previously developed 5 point scale, with a score of 3 or 4 considered a positive outcome. RESULTS: All animals were grouped into a single cohort for analysis as no difference in the rate of CM or healing was seen in the four treatment groups. Significant interaction between the absence of CM and a positive outcome was confirmed by Fisher exact test (P=0.0034). Angioplasty was shown to treat 33% of the cases of CM seen at implant, and these treated cases overwhelmingly had a positive outcome (P < 0.001). CONCLUSION: The use of OCT to assess CM of flow diverters has been shown to be predictive of the 30 day healing rate of an animal model of aneurysms.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=29127197&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1136/neurintsurg-2017-013502
dc.subjectaneurysm
dc.subjectdevice
dc.subjectflow diverter
dc.subjectAnalytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectCardiovascular Diseases
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectRadiology
dc.subjectSurgery
dc.titleCommunicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion
dc.typeJournal Article
dc.source.journaltitleJournal of neurointerventional surgery
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/361
dc.identifier.contextkey11314507
html.description.abstract<p>BACKGROUND: Optical coherence tomography (OCT) is a high resolution intravascular imaging method that allows visualization of flow diverter struts and the vessel wall. In this study, malapposition of the flow diverter that continues into the neck of the aneurysm, named communicating malapposition (CM), was investigated as a potential factor for delayed aneurysm healing.</p> <p>METHODS: 40 New Zealand White rabbits underwent elastase induced aneurysm creation, and were subsequently assigned to one of four treatment groups based on flow diverter type and administration of antiplatelet therapy. All animals underwent post device deployment balloon angioplasty and subsequent OCT to assess device/vessel apposition. The incidence of CM seen on OCT was assessed with a binary scoring system: 0-CM present; 1-CM absent. At 30 days, DSA was acquired to assess aneurysm healing. Aneurysm healing on terminal DSA was measured using a previously developed 5 point scale, with a score of 3 or 4 considered a positive outcome.</p> <p>RESULTS: All animals were grouped into a single cohort for analysis as no difference in the rate of CM or healing was seen in the four treatment groups. Significant interaction between the absence of CM and a positive outcome was confirmed by Fisher exact test (P=0.0034). Angioplasty was shown to treat 33% of the cases of CM seen at implant, and these treated cases overwhelmingly had a positive outcome (P < 0.001).</p> <p>CONCLUSION: The use of OCT to assess CM of flow diverters has been shown to be predictive of the 30 day healing rate of an animal model of aneurysms.</p>
dc.identifier.submissionpathradiology_pubs/361
dc.contributor.departmentDepartment of Radiology, New England Center for Stroke Research


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