Show simple item record

dc.contributor.authorMarosfoi, Miklos G.
dc.contributor.authorLangan, Erin T.
dc.contributor.authorStrittmatter, Lara
dc.contributor.authorvan der Marel, Kajo
dc.contributor.authorVedantham, Srinivasan
dc.contributor.authorArends, Jennifer
dc.contributor.authorLylyk, Ivan R.
dc.contributor.authorLoganathan, Siddharth
dc.contributor.authorHendricks, Gregory M.
dc.contributor.authorSzikora, Istvan
dc.contributor.authorPuri, Ajit S.
dc.contributor.authorWakhloo, Ajay K.
dc.contributor.authorGounis, Matthew J.
dc.date2022-08-11T08:10:47.000
dc.date.accessioned2022-08-23T17:20:23Z
dc.date.available2022-08-23T17:20:23Z
dc.date.issued2017-10-01
dc.date.submitted2018-06-11
dc.identifier.citation<p>J Neurointerv Surg. 2017 Oct;9(10):994-998. doi: 10.1136/neurintsurg-2016-012669. Epub 2016 Oct 5. <a href="https://doi.org/10.1136/neurintsurg-2016-012669">Link to article on publisher's site</a></p>
dc.identifier.issn1759-8478 (Linking)
dc.identifier.doi10.1136/neurintsurg-2016-012669
dc.identifier.pmid27707872
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48289
dc.description.abstractBACKGROUND: Vascular remodeling in response to implantation of a tissue engineering scaffold such as a flow diverter (FD) leads to the cure of intracranial aneurysms. We hypothesize that the vascular response is dependent on FD design, and CD34+ progenitor cells play an important role in the endothelialization of the implant. METHODS: Sixteen rabbit aneurysms were randomly treated with two different single-layer braided FDs made of cobalt-chrome alloys. The FD-48 and FD-72 devices had 48 and 72 wires, respectively. Aneurysm occlusion rate was assessed during the final digital subtraction angiogram at 10, 20, 30, and 60 days (n=2 per device per time point). Implanted vessels were analyzed with scanning electron microscopy for tissue coverage, endothelialization, and immuno-gold labeling for CD34+ cells. RESULTS: Complete aneurysm occlusion rates were similar between the devices; however, complete or near complete occlusion was more frequently observed in aneurysms with neck < /=4.2 mm (p=0.008). Total tissue coverage at 10 days over the surface of the FD-48 and FD-72 devices was 56.4+/-11.6% and 76.6+/-3.6%, respectively. Endothelial cell growth over the surface was time-dependent for the FD-72 device (Spearman's r=0.86, p=0.013) but not for the FD-48 device (Spearman's r=-0.59, p=0.094). The endothelialization score was marginally correlated with the distance from the aneurysm neck for the FD-48 device (Spearman's r=1, p=0.083) but not for the FD-72 device (Spearman's r=0.8, p=0.33). CD34+ cells were present along the entirety of both devices at all time points. CONCLUSIONS: This study gives preliminary evidence that temporal and spatial endothelialization is dependent on FD design. Circulating CD34+ progenitor cells contribute to endothelialization throughout the healing process.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27707872&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1136/neurintsurg-2016-012669
dc.subjectAneurysm
dc.subjectFlow Diverter
dc.subjectBiomedical Devices and Instrumentation
dc.subjectMolecular, Cellular, and Tissue Engineering
dc.subjectNeurology
dc.subjectRadiology
dc.subjectSurgery
dc.titleIn situ tissue engineering: endothelial growth patterns as a function of flow diverter design
dc.typeJournal Article
dc.source.journaltitleJournal of neurointerventional surgery
dc.source.volume9
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/400
dc.identifier.contextkey12289699
html.description.abstract<p>BACKGROUND: Vascular remodeling in response to implantation of a tissue engineering scaffold such as a flow diverter (FD) leads to the cure of intracranial aneurysms. We hypothesize that the vascular response is dependent on FD design, and CD34+ progenitor cells play an important role in the endothelialization of the implant.</p> <p>METHODS: Sixteen rabbit aneurysms were randomly treated with two different single-layer braided FDs made of cobalt-chrome alloys. The FD-48 and FD-72 devices had 48 and 72 wires, respectively. Aneurysm occlusion rate was assessed during the final digital subtraction angiogram at 10, 20, 30, and 60 days (n=2 per device per time point). Implanted vessels were analyzed with scanning electron microscopy for tissue coverage, endothelialization, and immuno-gold labeling for CD34+ cells.</p> <p>RESULTS: Complete aneurysm occlusion rates were similar between the devices; however, complete or near complete occlusion was more frequently observed in aneurysms with neck < /=4.2 mm (p=0.008). Total tissue coverage at 10 days over the surface of the FD-48 and FD-72 devices was 56.4+/-11.6% and 76.6+/-3.6%, respectively. Endothelial cell growth over the surface was time-dependent for the FD-72 device (Spearman's r=0.86, p=0.013) but not for the FD-48 device (Spearman's r=-0.59, p=0.094). The endothelialization score was marginally correlated with the distance from the aneurysm neck for the FD-48 device (Spearman's r=1, p=0.083) but not for the FD-72 device (Spearman's r=0.8, p=0.33). CD34+ cells were present along the entirety of both devices at all time points.</p> <p>CONCLUSIONS: This study gives preliminary evidence that temporal and spatial endothelialization is dependent on FD design. Circulating CD34+ progenitor cells contribute to endothelialization throughout the healing process.</p>
dc.identifier.submissionpathradiology_pubs/400
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentNew England Center for Stroke Research
dc.contributor.departmentDepartment of Radiology
dc.source.pages994-998


This item appears in the following Collection(s)

Show simple item record