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    Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT

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    Authors
    Juan Ramon, Albert
    Yang, Yongyi
    Wernick, Miles N.
    Pretorius, P. Hendrik
    Johnson, Karen L.
    Slomka, Piotr J.
    King, Michael A.
    UMass Chan Affiliations
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2018-11-07
    Keywords
    CAD
    MPI
    SPECT
    gated SPECT
    image reconstruction
    Cardiology
    Radiology
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1007/s12350-018-01505-x
    Abstract
    BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function. METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 +/- 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we considered both filtered backprojection (FBP) without correction for degradations, and iterative ordered-subsets expectation-maximization (OS-EM) with resolution, attenuation and scatter corrections. RESULTS: With dose level lowered to 25% of full dose, the obtained results on motion/thickening, EF and abnormal motion detection were statistically comparable to full dose in both reconstruction strategies, with Pearson's r > 0.9 for global motion measures between low dose and full dose. CONCLUSIONS: The administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT.
    Source

    J Nucl Cardiol. 2018 Nov 7. doi: 10.1007/s12350-018-01505-x. [Epub ahead of print] Link to article on publisher's site

    DOI
    10.1007/s12350-018-01505-x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48324
    PubMed ID
    30406608
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1007/s12350-018-01505-x
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