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dc.contributor.authorJuan Ramon, Albert
dc.contributor.authorYang, Yongyi
dc.contributor.authorWernick, Miles N.
dc.contributor.authorPretorius, P. Hendrik
dc.contributor.authorJohnson, Karen L.
dc.contributor.authorSlomka, Piotr J.
dc.contributor.authorKing, Michael A.
dc.date2022-08-11T08:10:48.000
dc.date.accessioned2022-08-23T17:20:32Z
dc.date.available2022-08-23T17:20:32Z
dc.date.issued2018-11-07
dc.date.submitted2018-12-17
dc.identifier.citation<p>J Nucl Cardiol. 2018 Nov 7. doi: 10.1007/s12350-018-01505-x. [Epub ahead of print] <a href="https://doi.org/10.1007/s12350-018-01505-x">Link to article on publisher's site</a></p>
dc.identifier.issn1071-3581 (Linking)
dc.identifier.doi10.1007/s12350-018-01505-x
dc.identifier.pmid30406608
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48324
dc.description.abstractBACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function. METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 +/- 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we considered both filtered backprojection (FBP) without correction for degradations, and iterative ordered-subsets expectation-maximization (OS-EM) with resolution, attenuation and scatter corrections. RESULTS: With dose level lowered to 25% of full dose, the obtained results on motion/thickening, EF and abnormal motion detection were statistically comparable to full dose in both reconstruction strategies, with Pearson's r > 0.9 for global motion measures between low dose and full dose. CONCLUSIONS: The administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30406608&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1007/s12350-018-01505-x
dc.subjectCAD
dc.subjectMPI
dc.subjectSPECT
dc.subjectgated SPECT
dc.subjectimage reconstruction
dc.subjectCardiology
dc.subjectRadiology
dc.titleEvaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT
dc.typeJournal Article
dc.source.journaltitleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/434
dc.identifier.contextkey13496583
html.description.abstract<p>BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function.</p> <p>METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 +/- 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we considered both filtered backprojection (FBP) without correction for degradations, and iterative ordered-subsets expectation-maximization (OS-EM) with resolution, attenuation and scatter corrections.</p> <p>RESULTS: With dose level lowered to 25% of full dose, the obtained results on motion/thickening, EF and abnormal motion detection were statistically comparable to full dose in both reconstruction strategies, with Pearson's r > 0.9 for global motion measures between low dose and full dose.</p> <p>CONCLUSIONS: The administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT.</p>
dc.identifier.submissionpathradiology_pubs/434
dc.contributor.departmentDepartment of Radiology


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