Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT
dc.contributor.author | Juan Ramon, Albert | |
dc.contributor.author | Yang, Yongyi | |
dc.contributor.author | Wernick, Miles N. | |
dc.contributor.author | Pretorius, P. Hendrik | |
dc.contributor.author | Johnson, Karen L. | |
dc.contributor.author | Slomka, Piotr J. | |
dc.contributor.author | King, Michael A. | |
dc.date | 2022-08-11T08:10:48.000 | |
dc.date.accessioned | 2022-08-23T17:20:32Z | |
dc.date.available | 2022-08-23T17:20:32Z | |
dc.date.issued | 2018-11-07 | |
dc.date.submitted | 2018-12-17 | |
dc.identifier.citation | <p>J Nucl Cardiol. 2018 Nov 7. doi: 10.1007/s12350-018-01505-x. [Epub ahead of print] <a href="https://doi.org/10.1007/s12350-018-01505-x">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 1071-3581 (Linking) | |
dc.identifier.doi | 10.1007/s12350-018-01505-x | |
dc.identifier.pmid | 30406608 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/48324 | |
dc.description.abstract | BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function. METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 +/- 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we considered both filtered backprojection (FBP) without correction for degradations, and iterative ordered-subsets expectation-maximization (OS-EM) with resolution, attenuation and scatter corrections. RESULTS: With dose level lowered to 25% of full dose, the obtained results on motion/thickening, EF and abnormal motion detection were statistically comparable to full dose in both reconstruction strategies, with Pearson's r > 0.9 for global motion measures between low dose and full dose. CONCLUSIONS: The administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30406608&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.relation.url | https://doi.org/10.1007/s12350-018-01505-x | |
dc.subject | CAD | |
dc.subject | MPI | |
dc.subject | SPECT | |
dc.subject | gated SPECT | |
dc.subject | image reconstruction | |
dc.subject | Cardiology | |
dc.subject | Radiology | |
dc.title | Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT | |
dc.type | Journal Article | |
dc.source.journaltitle | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/radiology_pubs/434 | |
dc.identifier.contextkey | 13496583 | |
html.description.abstract | <p>BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function.</p> <p>METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 +/- 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we considered both filtered backprojection (FBP) without correction for degradations, and iterative ordered-subsets expectation-maximization (OS-EM) with resolution, attenuation and scatter corrections.</p> <p>RESULTS: With dose level lowered to 25% of full dose, the obtained results on motion/thickening, EF and abnormal motion detection were statistically comparable to full dose in both reconstruction strategies, with Pearson's r > 0.9 for global motion measures between low dose and full dose.</p> <p>CONCLUSIONS: The administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT.</p> | |
dc.identifier.submissionpath | radiology_pubs/434 | |
dc.contributor.department | Department of Radiology |
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