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dc.contributor.authorLiu, Guozheng
dc.date2022-08-11T08:10:48.000
dc.date.accessioned2022-08-23T17:20:35Z
dc.date.available2022-08-23T17:20:35Z
dc.date.issued2018-12-17
dc.date.submitted2019-03-20
dc.identifier.citation<p>Front Pharmacol. 2018 Dec 17;9:1476. doi: 10.3389/fphar.2018.01476. eCollection 2018. <a href="https://doi.org/10.3389/fphar.2018.01476">Link to article on publisher's site</a></p>
dc.identifier.issn1663-9812 (Linking)
dc.identifier.doi10.3389/fphar.2018.01476
dc.identifier.pmid30618765
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48333
dc.description.abstractPretargeting is often used as a tumor targeting strategy that provides much higher tumor to non-tumor ratios than direct-targeting using radiolabeled antibody. Due to the multiple injections, pretargeting is investigated less than direct targeting, but the high T/NT ratios have rendered it more useful for therapy. While the progress in using this strategy for tumor therapy has been regularly reviewed in the literature, this review focuses on the nature and quantitative understanding of the pretargeting concept. By doing so, it is the goal of this review to accelerate pretargeting development and translation to the clinic and to prepare the researchers who are not familiar with the pretargeting concept but are interested in applying it. The quantitative understanding is presented in a way understandable to the average researchers in the areas of drug development and clinical translation who have the basic concept of calculus and general chemistry.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30618765&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2018 Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectpretargeting
dc.subjectquantitative correlation
dc.subjectsemi-empirical model
dc.subjecttarget conversion
dc.subjecttumor accumulation
dc.subjectMedical Pharmacology
dc.subjectNeoplasms
dc.subjectPharmacology
dc.subjectRadiology
dc.titleA Revisit to the Pretargeting Concept - A Target Conversion
dc.typeJournal Article
dc.source.journaltitleFrontiers in pharmacology
dc.source.volume9
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1454&amp;context=radiology_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/444
dc.identifier.contextkey14067398
refterms.dateFOA2022-08-23T17:20:35Z
html.description.abstract<p>Pretargeting is often used as a tumor targeting strategy that provides much higher tumor to non-tumor ratios than direct-targeting using radiolabeled antibody. Due to the multiple injections, pretargeting is investigated less than direct targeting, but the high T/NT ratios have rendered it more useful for therapy. While the progress in using this strategy for tumor therapy has been regularly reviewed in the literature, this review focuses on the nature and quantitative understanding of the pretargeting concept. By doing so, it is the goal of this review to accelerate pretargeting development and translation to the clinic and to prepare the researchers who are not familiar with the pretargeting concept but are interested in applying it. The quantitative understanding is presented in a way understandable to the average researchers in the areas of drug development and clinical translation who have the basic concept of calculus and general chemistry.</p>
dc.identifier.submissionpathradiology_pubs/444
dc.contributor.departmentDepartment of Radiology
dc.source.pages1476


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Copyright © 2018 Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Copyright © 2018 Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.