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    Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

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    Authors
    Herrmann, Andrea M.
    Meckel, Stephan
    Gounis, Matthew J.
    Kringe, Leona
    Motschall, Edith
    Mulling, Christoph
    Boltze, Johannes
    UMass Chan Affiliations
    Department of Radiology, New England Center for Stroke Research
    Document Type
    Journal Article
    Publication Date
    2019-02-07
    Keywords
    Endovascular
    aneurysm
    arteriovenous malformations
    large animal models
    stroke
    Animal Experimentation and Research
    Cardiovascular Diseases
    Nervous System Diseases
    Neurology
    Radiology
    
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    Link to Full Text
    https://doi.org/10.1177/0271678X19827446
    Abstract
    Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.
    Source

    J Cereb Blood Flow Metab. 2019 Mar;39(3):375-394. doi: 10.1177/0271678X19827446. Epub 2019 Feb 7. Link to article on publisher's site

    DOI
    10.1177/0271678X19827446
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48336
    PubMed ID
    30732549
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1177/0271678X19827446
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