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dc.contributor.authorHerrmann, Andrea M.
dc.contributor.authorMeckel, Stephan
dc.contributor.authorGounis, Matthew J.
dc.contributor.authorKringe, Leona
dc.contributor.authorMotschall, Edith
dc.contributor.authorMulling, Christoph
dc.contributor.authorBoltze, Johannes
dc.date2022-08-11T08:10:48.000
dc.date.accessioned2022-08-23T17:20:36Z
dc.date.available2022-08-23T17:20:36Z
dc.date.issued2019-02-07
dc.date.submitted2019-03-20
dc.identifier.citation<p>J Cereb Blood Flow Metab. 2019 Mar;39(3):375-394. doi: 10.1177/0271678X19827446. Epub 2019 Feb 7. <a href="https://doi.org/10.1177/0271678X19827446">Link to article on publisher's site</a></p>
dc.identifier.issn0271-678X (Linking)
dc.identifier.doi10.1177/0271678X19827446
dc.identifier.pmid30732549
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48336
dc.description.abstractNeuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30732549&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1177/0271678X19827446
dc.subjectEndovascular
dc.subjectaneurysm
dc.subjectarteriovenous malformations
dc.subjectlarge animal models
dc.subjectstroke
dc.subjectCardiovascular Diseases
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectRadiology
dc.titleLarge animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations
dc.typeJournal Article
dc.source.journaltitleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
dc.source.volume39
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/447
dc.identifier.contextkey14067402
html.description.abstract<p>Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.</p>
dc.identifier.submissionpathradiology_pubs/447
dc.contributor.departmentDepartment of Radiology, New England Center for Stroke Research
dc.source.pages375-394


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