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    A brief evaluation of tumor imaging in mice with 99mTc-glucarate including a comparison with 18F-FDG

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    Authors
    Cheng, Dengfeng
    Rusckowski, Mary
    Wang, Yuzhen
    Liu, Yuxia
    Liu, Guozheng
    Liu, Xinrong
    Hnatowich, Donald J.
    UMass Chan Affiliations
    Department of Radiology, Division of Nuclear Medicine
    Document Type
    Journal Article
    Publication Date
    2011-01-01
    Keywords
    Animals
    Female
    Fluorodeoxyglucose F18
    Glucaric Acid
    Mice
    Mice, Nude
    Neoplasm Transplantation
    Neoplasms
    Organotechnetium Compounds
    Positron-Emission Tomography
    Radiopharmaceuticals
    Tomography, Emission-Computed, Single-Photon
    Transplantation, Heterologous
    Tumor Cells, Cultured
    18F-FDG
    99mTc-glucarate
    positron emission tomography (PET)
    single photon emission computed tomography (SPECT)
    molecular imaging
    tumor
    Small Animal SPECT/CT
    Radioactive Tracers
    PET
    Tumor Model
    Cancer Biology
    Medicinal and Pharmaceutical Chemistry
    Medicinal-Pharmaceutical Chemistry
    Radiology
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    Link to Full Text
    http://dx.doi.org/10.2174/1874471011104010005
    Abstract
    OBJECTIVE: Recently 99mTc-glucarate, a radiolabeled glucose analogue, has been considered as a SPECT alternative to 18F-FDG and PET for non-invasive detection of certain tumors. Thus far there have been few studies on (99m) Tcglucarate for tumor imaging and fewer, if any, studies comparing (99m)Tc-glucarate with 18F-FDG. As a preliminary indication of the properties of (99m)Tc-glucarate as a possible substitute for 18F-FDG in animal studies, we have imaged mice bearing xenografts of four tumor types with (99m)Tc-glucarate and have compared in two mice with one of these tumor types the 99mTc and 18F biodistributions. METHODS: Two mice bearing SUM190 breast cancer xenografts received 1 mCi of (99m)Tc-glucarate and were imaged on a NanoSPECT/CT small animal camera. One day later, the same animals received 1 mCi of 18F-FDG and were imaged on a MosaicHP PET small animal camera. In addition, 0.5-1 mCi of (99m)Tc-glucarate only was administered to mice bearing xenografts induced by BxPC3 pancreatic cancer cells, HEK-293 renal cell carcinomas cells or HCT-116 colorectal tumor cells. NanoSPECT/CT acquisitions were performed in these mice to evaluate tumor accumulations. RESULTS: In the SUM190 xenografted mice, the average tumor accumulation was 1.4 % (ID%/cm3) for (99m)Tc-glucarate and 2.1 % (ID%/cm3) for 18F-FDG. While slightly higher than (99m)Tc-glucarate, the tumor accumulation of 18F-FDG was accompanied by higher bone marrow and muscle accumulations at levels that could interfere with the tumor image depending upon location. The whole body clearance of (99m)Tc-glucarate was faster than that of 18F-FDG. Tumor accumulation of (99m)Tc-glucarate varied among tumor types but the tumors were readily visible in all images. CONCLUSION: In a direct comparison in the same two SUM190 tumored animals, SPECT images obtained with (99m)Tcglucarate compared favorably with PET images obtained with 18F-FDG. Tumor images with 99mTc-glucarate were also positive in three additional tumor mouse models. While further comparison studies are necessary, we conclude that (99m)Tcglucarate may be a more convenient and less expensive alternative to 18F-FDG for tumored mouse studies.
    Source
    Curr Radiopharm. 2011 Jan;4(1):5-9. DOI: 10.2174/1874471011104010005
    DOI
    10.2174/1874471011104010005
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48349
    PubMed ID
    22191610
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.2174/1874471011104010005
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