Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

Authors
Rodriguez-Rodriguez, Aurora
Shuvaev, Sergey
Rotile, Nicholas
Jones, Chloe M.
Probst, Clemens K.
Dos Santos Ferreira, Diego
Graham-O Regan, Katherine
Boros, Eszter
Knipe, Rachel S.
Griffith, Jason W.
UMass Chan Affiliations
Department of Radiology
Document Type
Journal Article
Publication Date
2019-08-09
Keywords
5-hydroxytryptamide
MRI
contrast agent
gadolinium
pulmonary fibrosis
Chemical Actions and Uses
Chemistry
Enzymes and Coenzymes
Radiology
Respiratory Tract Diseases

Metadata
Show full item record
Link to Full Text
https://doi.org/10.1021/acssensors.9b01010
Abstract
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
Source

ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site
DOI
10.1021/acssensors.9b01010
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48382
PubMed ID
31397156
Related Resources

Link to Article in PubMed
Collections