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    Biomechanics and hemodynamics of stent-retrievers

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    Authors
    Kuhn, Anna L.
    Vardar, Zeynep
    Kraitem, Afif
    King, Robert M.
    Anagnostakou, Vania
    Puri, Ajit S.
    Gounis, Matthew J.
    UMass Chan Affiliations
    Department of Radiology
    New England Center for Stroke Research
    Document Type
    Journal Article
    Publication Date
    2020-05-19
    Keywords
    endovascular
    stent-retriever
    Acute ischemic stroke
    large vessel occlusion
    thrombectomy
    Analytical, Diagnostic and Therapeutic Techniques and Equipment
    Biomechanics and Biotransport
    Cardiovascular Diseases
    Nervous System Diseases
    Neurology
    Neurosurgery
    Radiology
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    Link to Full Text
    https://doi.org/10.1177/0271678x20916002
    Abstract
    In 2015, multiple randomized clinical trials showed an unparalleled treatment benefit of stent-retriever thrombectomy as compared to standard medical therapy for the treatment of a large artery occlusion causing acute ischemic stroke. A short time later, the HERMES collaborators presented the patient-level pooled analysis of five randomized clinical trials, establishing class 1, level of evidence A for stent-retriever thrombectomy, in combination with intravenous thrombolysis when indicated to treat ischemic stroke. In the years following, evidence continues to mount for expanded use of this therapy for a broader category of patients. The enabling technology that changed the tide to support endovascular treatment of acute ischemic stroke is the stent-retriever. This review summarizes the history of intra-arterial treatment of stroke, introduces the biomechanics of embolus extraction with stent-retrievers, describes technical aspects of the intervention, provides a description of hemodynamic implications of stent-retriever embolectomy, and proposes future directions for a more comprehensive, multi-modal endovascular approach for the treatment of acute ischemic stroke.
    Source

    Kühn AL, Vardar Z, Kraitem A, King RM, Anagnostakou V, Puri AS, Gounis MJ. Biomechanics and hemodynamics of stent-retrievers. J Cereb Blood Flow Metab. 2020 May 19:271678X20916002. doi: 10.1177/0271678X20916002. Epub ahead of print. PMID: 32428424. Link to article on publisher's site

    DOI
    10.1177/0271678X20916002
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48438
    PubMed ID
    32428424
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    ae974a485f413a2113503eed53cd6c53
    10.1177/0271678X20916002
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