Authors
Kuhn, Anna L.Vardar, Zeynep
Kraitem, Afif
King, Robert M.
Anagnostakou, Vania
Puri, Ajit S.
Gounis, Matthew J.
Document Type
Journal ArticlePublication Date
2020-05-19Keywords
endovascularstent-retriever
Acute ischemic stroke
large vessel occlusion
thrombectomy
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biomechanics and Biotransport
Cardiovascular Diseases
Nervous System Diseases
Neurology
Neurosurgery
Radiology
Metadata
Show full item recordAbstract
In 2015, multiple randomized clinical trials showed an unparalleled treatment benefit of stent-retriever thrombectomy as compared to standard medical therapy for the treatment of a large artery occlusion causing acute ischemic stroke. A short time later, the HERMES collaborators presented the patient-level pooled analysis of five randomized clinical trials, establishing class 1, level of evidence A for stent-retriever thrombectomy, in combination with intravenous thrombolysis when indicated to treat ischemic stroke. In the years following, evidence continues to mount for expanded use of this therapy for a broader category of patients. The enabling technology that changed the tide to support endovascular treatment of acute ischemic stroke is the stent-retriever. This review summarizes the history of intra-arterial treatment of stroke, introduces the biomechanics of embolus extraction with stent-retrievers, describes technical aspects of the intervention, provides a description of hemodynamic implications of stent-retriever embolectomy, and proposes future directions for a more comprehensive, multi-modal endovascular approach for the treatment of acute ischemic stroke.Source
Kühn AL, Vardar Z, Kraitem A, King RM, Anagnostakou V, Puri AS, Gounis MJ. Biomechanics and hemodynamics of stent-retrievers. J Cereb Blood Flow Metab. 2020 May 19:271678X20916002. doi: 10.1177/0271678X20916002. Epub ahead of print. PMID: 32428424. Link to article on publisher's site
DOI
10.1177/0271678X20916002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48438PubMed ID
32428424Related Resources
ae974a485f413a2113503eed53cd6c53
10.1177/0271678X20916002