Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography
dc.contributor.author | Caroff, Jildaz | |
dc.contributor.author | King, Robert M. | |
dc.contributor.author | Ughi, Giovanni J. | |
dc.contributor.author | Marosfoi, Miklos G. | |
dc.contributor.author | Langan, Erin T. | |
dc.contributor.author | Raskett, Christopher M. | |
dc.contributor.author | Puri, Ajit S. | |
dc.contributor.author | Gounis, Matthew J. | |
dc.date | 2022-08-11T08:10:49.000 | |
dc.date.accessioned | 2022-08-23T17:21:04Z | |
dc.date.available | 2022-08-23T17:21:04Z | |
dc.date.issued | 2020-05-28 | |
dc.date.submitted | 2020-06-17 | |
dc.identifier.citation | <p>Caroff J, King RM, Ughi GJ, Marosfoi M, Langan ET, Raskett C, Puri AS, Gounis MJ. Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography. Neurosurgery. 2020 May 28:nyaa208. doi: 10.1093/neuros/nyaa208. Epub ahead of print. PMID: 32463884. <a href="https://doi.org/10.1093/neuros/nyaa208">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 0148-396X (Linking) | |
dc.identifier.doi | 10.1093/neuros/nyaa208 | |
dc.identifier.pmid | 32463884 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/48440 | |
dc.description.abstract | BACKGROUND: Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon. OBJECTIVE: To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approaching 10 microns, to monitor tissue growth over FDS in an arterial bifurcation model. METHODS: FDS were deployed in a rabbit model (n = 6), covering the aortic bifurcation. The animals were divided in different groups, receiving dual antiplatelet therapy (DAPT) (n = 4), aspirin only (n = 1), and no treatment (n = 1). HF-OCT data were obtained in vivo at 3 different time points in each animal. For each cross-sectional image, metal and tissue coverage of the jailed ostium was quantified. Scanning electron microscopy images of harvested arteries were subsequently obtained. RESULTS: Good quality HF-OCT data sets were successfully acquired at implant and follow-up. A median value of 41 (range 21-55) cross-sectional images were analyzed per ostium for each time point. Between 0 and 30 d after implant, HF-OCT analysis showed a significantly higher ostium coverage when DAPT was not given. After 30 d, similar growth rates were found in the DAPT and in the aspirin group. At 60 d, a coverage of 90% was reached in all groups. CONCLUSION: HF-OCT enables an accurate visualization of tissue growth over time on FDS struts. The use of FDS in bifurcation locations may induce a drastic reduction of the jailed-branch ostium area. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32463884&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.relation.url | https://doi.org/10.1093/neuros/nyaa208 | |
dc.subject | Endothelialization | |
dc.subject | Flow diverter | |
dc.subject | Intracranial aneurysm | |
dc.subject | Optical coherence tomography | |
dc.subject | aspirin | |
dc.subject | stents | |
dc.subject | heart failure | |
dc.subject | follow-up | |
dc.subject | oryctolagus cuniculus | |
dc.subject | diagnostic imaging | |
dc.subject | optical coherence tomography | |
dc.subject | implants | |
dc.subject | aortic bifurcation | |
dc.subject | fluid flow | |
dc.subject | dual anti-platelet therapy | |
dc.subject | datasets | |
dc.subject | Analytical, Diagnostic and Therapeutic Techniques and Equipment | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Nervous System Diseases | |
dc.subject | Neurosurgery | |
dc.subject | Radiology | |
dc.title | Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography | |
dc.type | Journal Article | |
dc.source.journaltitle | Neurosurgery | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/radiology_pubs/547 | |
dc.identifier.contextkey | 18142188 | |
html.description.abstract | <p>BACKGROUND: Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon.</p> <p>OBJECTIVE: To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approaching 10 microns, to monitor tissue growth over FDS in an arterial bifurcation model.</p> <p>METHODS: FDS were deployed in a rabbit model (n = 6), covering the aortic bifurcation. The animals were divided in different groups, receiving dual antiplatelet therapy (DAPT) (n = 4), aspirin only (n = 1), and no treatment (n = 1). HF-OCT data were obtained in vivo at 3 different time points in each animal. For each cross-sectional image, metal and tissue coverage of the jailed ostium was quantified. Scanning electron microscopy images of harvested arteries were subsequently obtained.</p> <p>RESULTS: Good quality HF-OCT data sets were successfully acquired at implant and follow-up. A median value of 41 (range 21-55) cross-sectional images were analyzed per ostium for each time point. Between 0 and 30 d after implant, HF-OCT analysis showed a significantly higher ostium coverage when DAPT was not given. After 30 d, similar growth rates were found in the DAPT and in the aspirin group. At 60 d, a coverage of 90% was reached in all groups.</p> <p>CONCLUSION: HF-OCT enables an accurate visualization of tissue growth over time on FDS struts. The use of FDS in bifurcation locations may induce a drastic reduction of the jailed-branch ostium area.</p> | |
dc.identifier.submissionpath | radiology_pubs/547 | |
dc.contributor.department | New England Center for Stroke Research | |
dc.contributor.department | Department of Radiology |
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