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dc.contributor.authorCaroff, Jildaz
dc.contributor.authorKing, Robert M.
dc.contributor.authorUghi, Giovanni J.
dc.contributor.authorMarosfoi, Miklos G.
dc.contributor.authorLangan, Erin T.
dc.contributor.authorRaskett, Christopher M.
dc.contributor.authorPuri, Ajit S.
dc.contributor.authorGounis, Matthew J.
dc.date2022-08-11T08:10:49.000
dc.date.accessioned2022-08-23T17:21:04Z
dc.date.available2022-08-23T17:21:04Z
dc.date.issued2020-05-28
dc.date.submitted2020-06-17
dc.identifier.citation<p>Caroff J, King RM, Ughi GJ, Marosfoi M, Langan ET, Raskett C, Puri AS, Gounis MJ. Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography. Neurosurgery. 2020 May 28:nyaa208. doi: 10.1093/neuros/nyaa208. Epub ahead of print. PMID: 32463884. <a href="https://doi.org/10.1093/neuros/nyaa208">Link to article on publisher's site</a></p>
dc.identifier.issn0148-396X (Linking)
dc.identifier.doi10.1093/neuros/nyaa208
dc.identifier.pmid32463884
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48440
dc.description.abstractBACKGROUND: Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon. OBJECTIVE: To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approaching 10 microns, to monitor tissue growth over FDS in an arterial bifurcation model. METHODS: FDS were deployed in a rabbit model (n = 6), covering the aortic bifurcation. The animals were divided in different groups, receiving dual antiplatelet therapy (DAPT) (n = 4), aspirin only (n = 1), and no treatment (n = 1). HF-OCT data were obtained in vivo at 3 different time points in each animal. For each cross-sectional image, metal and tissue coverage of the jailed ostium was quantified. Scanning electron microscopy images of harvested arteries were subsequently obtained. RESULTS: Good quality HF-OCT data sets were successfully acquired at implant and follow-up. A median value of 41 (range 21-55) cross-sectional images were analyzed per ostium for each time point. Between 0 and 30 d after implant, HF-OCT analysis showed a significantly higher ostium coverage when DAPT was not given. After 30 d, similar growth rates were found in the DAPT and in the aspirin group. At 60 d, a coverage of 90% was reached in all groups. CONCLUSION: HF-OCT enables an accurate visualization of tissue growth over time on FDS struts. The use of FDS in bifurcation locations may induce a drastic reduction of the jailed-branch ostium area.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32463884&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1093/neuros/nyaa208
dc.subjectEndothelialization
dc.subjectFlow diverter
dc.subjectIntracranial aneurysm
dc.subjectOptical coherence tomography
dc.subjectaspirin
dc.subjectstents
dc.subjectheart failure
dc.subjectfollow-up
dc.subjectoryctolagus cuniculus
dc.subjectdiagnostic imaging
dc.subjectoptical coherence tomography
dc.subjectimplants
dc.subjectaortic bifurcation
dc.subjectfluid flow
dc.subjectdual anti-platelet therapy
dc.subjectdatasets
dc.subjectAnalytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectCardiovascular Diseases
dc.subjectNervous System Diseases
dc.subjectNeurosurgery
dc.subjectRadiology
dc.titleLongitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography
dc.typeJournal Article
dc.source.journaltitleNeurosurgery
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/547
dc.identifier.contextkey18142188
html.description.abstract<p>BACKGROUND: Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon.</p> <p>OBJECTIVE: To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approaching 10 microns, to monitor tissue growth over FDS in an arterial bifurcation model.</p> <p>METHODS: FDS were deployed in a rabbit model (n = 6), covering the aortic bifurcation. The animals were divided in different groups, receiving dual antiplatelet therapy (DAPT) (n = 4), aspirin only (n = 1), and no treatment (n = 1). HF-OCT data were obtained in vivo at 3 different time points in each animal. For each cross-sectional image, metal and tissue coverage of the jailed ostium was quantified. Scanning electron microscopy images of harvested arteries were subsequently obtained.</p> <p>RESULTS: Good quality HF-OCT data sets were successfully acquired at implant and follow-up. A median value of 41 (range 21-55) cross-sectional images were analyzed per ostium for each time point. Between 0 and 30 d after implant, HF-OCT analysis showed a significantly higher ostium coverage when DAPT was not given. After 30 d, similar growth rates were found in the DAPT and in the aspirin group. At 60 d, a coverage of 90% was reached in all groups.</p> <p>CONCLUSION: HF-OCT enables an accurate visualization of tissue growth over time on FDS struts. The use of FDS in bifurcation locations may induce a drastic reduction of the jailed-branch ostium area.</p>
dc.identifier.submissionpathradiology_pubs/547
dc.contributor.departmentNew England Center for Stroke Research
dc.contributor.departmentDepartment of Radiology


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