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    Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

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    Authors
    Zeraatkar, Navid
    Kalluri, Kesava S.
    Auer, Benjamin
    Konik, Arda
    Fromme, Timothy J.
    Furenlid, Lars R.
    Kuo, Phillip H.
    King, Michael A.
    UMass Chan Affiliations
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2020-08-07
    Keywords
    AdaptiSPECT-C
    angular and axial sampling
    SPECT
    pinhole
    multi-pinhole
    Bioimaging and Biomedical Optics
    Radiology
    
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    Abstract
    We designed a dedicated multi-detector multi-pinhole brain SPECT scanner to generate images of higher quality compared to general-purpose systems. The system, AdaptiSPECT-C, is intended to adapt its sensitivity-resolution trade-off by varying its aperture configurations allowing both high-sensitivity dynamic and high-spatial-resolution static imaging. The current system design consists of 23 detector heads arranged in a truncated spherical geometry. In this work, we investigated the axial and angular sampling capability of the current stationary system design. Two data acquisition schemes using limited rotation of the gantry and two others using axial translation of the imaging bed were also evaluated concerning their impact on image quality through improved sampling. Increasing both angular and axial sampling in the current prototype system resulted in quantitative improvements in image quality metrics and qualitative appearance of the images as determined in studies with specifically selected phantoms. Visual improvements for the brain phantoms with clinical distributions were less pronounced but presented quantitative improvements in the fidelity (normalized root-mean-square error (NRMSE)) and striatal specific binding ratio (SBR) for a dopamine transporter (DAT) distribution, and in NRMSE and activity recovery for a brain perfusion distribution. More pronounced improvements with increased sampling were seen in contrast recovery coefficient, bias, and coefficient of variation for a lesion in the brain perfusion distribution. The negligible impact of the most cranial ring of detectors on axial sampling, but its significant impact on sensitivity and angular sampling in the cranial portion of the imaging volume-of-interest were also determined.
    Source

    Zeraatkar N, Kalluri KS, Auer B, Konik A, Fromme TJ, Furenlid LR, Kuo PH, King MA. Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging. IEEE Trans Med Imaging. 2020 Aug 7;PP. doi: 10.1109/TMI.2020.3015079. Epub ahead of print. PMID: 32763850. Link to article on publisher's site

    DOI
    10.1109/TMI.2020.3015079
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48455
    PubMed ID
    32763850
    Related Resources

    Link to Article in PubMed

    Rights
    (c) 2020 IEEE. Accepted manuscript posted as allowed by the publisher's policy at https://www.ieee.org/publications/rights/author-posting-policy.html.
    ae974a485f413a2113503eed53cd6c53
    10.1109/TMI.2020.3015079
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