Show simple item record

dc.contributor.authorZong, Yang
dc.contributor.authorMontironi, Rodolfo
dc.contributor.authorMassari, Francesco
dc.contributor.authorJiang, Zhong
dc.contributor.authorLopez-Beltran, Antonio
dc.contributor.authorWheeler, Thomas M.
dc.contributor.authorScarpelli, Marina
dc.contributor.authorSantoni, Matteo
dc.contributor.authorCimadamore, Alessia
dc.contributor.authorCheng, Liang
dc.date2022-08-11T08:10:49.000
dc.date.accessioned2022-08-23T17:21:12Z
dc.date.available2022-08-23T17:21:12Z
dc.date.issued2020-10-29
dc.date.submitted2020-12-14
dc.identifier.citation<p>Zong Y, Montironi R, Massari F, Jiang Z, Lopez-Beltran A, Wheeler TM, Scarpelli M, Santoni M, Cimadamore A, Cheng L. Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives. Eur Urol Focus. 2020 Oct 29:S2405-4569(20)30291-1. doi: 10.1016/j.euf.2020.10.007. Epub ahead of print. PMID: 33132109. <a href="https://doi.org/10.1016/j.euf.2020.10.007">Link to article on publisher's site</a></p>
dc.identifier.issn2405-4569 (Linking)
dc.identifier.doi10.1016/j.euf.2020.10.007
dc.identifier.pmid33132109
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48469
dc.description.abstractIntraductal carcinoma of the prostate (IDC-P), a clinicopathological entity characterized by malignant prostatic epithelial cells growing within ducts and/or acini, has a distinct architectural pattern, cytological features, and biological behavior. Whereas most IDC-P tumors could be derived from adjacent high-grade invasive cancer via retrograde spreading of cancer cells along benign ducts and acini, a small subset of IDC-P may arise from the transformation and intraductal proliferation of precancerous cells induced by various oncogenic events. These isolated IDC-P tumors possess a distinct mutational profile and may function as a carcinoma in situ lesion with de novo intraductal outgrowth of malignant cells. Further molecular characterization of these two types of IDC-P and better understanding of the mechanisms underlying IDC-P formation and progression could be translated into valuable biomarkers for differential diagnosis and actionable targets for therapeutic interventions. PATIENT SUMMARY: Intraductal carcinoma of the prostate is an aggressive type of prostate cancer associated with high risk for local recurrence and distant metastasis. In this review, we discussed pathogenesis, biomarkers, differential diagnoses, and therapeutic strategies for this tumor.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=33132109&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/j.euf.2020.10.007
dc.subjectDifferential diagnosis
dc.subjectGermline DNA repair gene
dc.subjectGleason grading
dc.subjectIntraductal carcinoma of the prostate
dc.subjectMolecular genetics
dc.subjectProstate
dc.subjectMale Urogenital Diseases
dc.subjectNeoplasms
dc.subjectPathology
dc.subjectRadiology
dc.subjectUrology
dc.titleIntraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives
dc.typeJournal Article
dc.source.journaltitleEuropean urology focus
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/573
dc.identifier.contextkey20590161
html.description.abstract<p>Intraductal carcinoma of the prostate (IDC-P), a clinicopathological entity characterized by malignant prostatic epithelial cells growing within ducts and/or acini, has a distinct architectural pattern, cytological features, and biological behavior. Whereas most IDC-P tumors could be derived from adjacent high-grade invasive cancer via retrograde spreading of cancer cells along benign ducts and acini, a small subset of IDC-P may arise from the transformation and intraductal proliferation of precancerous cells induced by various oncogenic events. These isolated IDC-P tumors possess a distinct mutational profile and may function as a carcinoma in situ lesion with de novo intraductal outgrowth of malignant cells. Further molecular characterization of these two types of IDC-P and better understanding of the mechanisms underlying IDC-P formation and progression could be translated into valuable biomarkers for differential diagnosis and actionable targets for therapeutic interventions.</p> <p>PATIENT SUMMARY: Intraductal carcinoma of the prostate is an aggressive type of prostate cancer associated with high risk for local recurrence and distant metastasis. In this review, we discussed pathogenesis, biomarkers, differential diagnoses, and therapeutic strategies for this tumor.</p>
dc.identifier.submissionpathradiology_pubs/573
dc.contributor.departmentDepartment of Radiology
dc.contributor.departmentDepartment of Pathology


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record