Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation
Authors
Liu, GuozhengCheng, Dengfeng
Dou, Shuping
Chen, Xiangji
Liang, Min Min
Pretorius, P. Hendrik
Rusckowski, Mary
Hnatowich, Donald J.
UMass Chan Affiliations
Department of Radiology, Division of Nuclear MedicineDocument Type
Journal ArticlePublication Date
2009-09-01Keywords
AnimalsIndium Radioisotopes
Intestines
Mice
Morpholines
Morpholinos
Positron-Emission Tomography
Radiopharmaceuticals
Technetium Compounds
Tissue Distribution
Whole Body Imaging
Pretargeting
Anticancer
Antibodies
Tumor
Radioimmunotargeting
Bioimaging and Biomedical Optics
Radiology
Metadata
Show full item recordAbstract
PURPOSE: To reduce accumulation in the abdomen by MORF/cMORF pretargeting, 111In was compared to 99mTc as the radiolabel. PROCEDURES: After receiving either 99mTc (MAG3)-cMORF or 111In (DTPA)-cMORF, normal mice were imaged and sacrificed for pharmacokinetics. Thereafter, tumored mice were pretargeted withMORF-antibody, 48 h later were given an injection of 99mTc- or 111In-cMORF, and finally were imaged repeatedly. RESULTS: The cMORF biodistribution in both normal and pretargeted tumored mice was influenced by its radiolabel. While excretion of both 99mTc-cMORF and 111In-cMORF was rapid and mainly through the kidneys, about 2% of 99mTc accumulated in the intestines compared to essentially no intestinal accumulation for 111In at any time. Tumor accumulation was unchanged. CONCLUSION: In applications of MORF/cMORF pretargeting intended to image organs deep within the abdomen such as the pancreas, radiolabeling with 111In may be superior to 99mTc.Source
Mol Imaging Biol. 2009 Sep-Oct;11(5):303-7.Link to article on publisher's site.Epub 2009 Mar 27.DOI
10.1007/s11307-009-0209-0Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48487PubMed ID
19326173Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s11307-009-0209-0