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dc.contributor.authorOspel, Johanna M.
dc.contributor.authorvan der Lugt, Aad
dc.contributor.authorGounis, Matthew J.
dc.contributor.authorGoyal, Mayank
dc.contributor.authorMajoie, Charles B. L. M.
dc.date2022-08-11T08:10:50.000
dc.date.accessioned2022-08-23T17:21:36Z
dc.date.available2022-08-23T17:21:36Z
dc.date.issued2021-10-11
dc.date.submitted2021-11-29
dc.identifier.citation<p>Ospel JM, van der Lugt A, Gounis M, Goyal M, Majoie CBLM. A clinical perspective on endovascular stroke treatment biomechanics. J Biomech. 2021 Oct 11;127:110694. doi: 10.1016/j.jbiomech.2021.110694. Epub 2021 Aug 14. PMID: 34419825. <a href="https://doi.org/10.1016/j.jbiomech.2021.110694">Link to article on publisher's site</a></p>
dc.identifier.issn0021-9290 (Linking)
dc.identifier.doi10.1016/j.jbiomech.2021.110694
dc.identifier.pmid34419825
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48557
dc.description.abstractAcute ischemic stroke (AIS) is caused by blockage of an arterial blood vessel in the brain by a thrombus, which interrupts oxygen supply to the brain parenchyma. The goal of endovascular stroke treatment (mechanical thrombectomy) is to restore blood flow as quickly and completely as possible. There are numerous factors that influence endovascular treatment success. They can be broadly grouped into a) factors related to blood vessels, b) factors related to the thrombus, c) factors related to endovascular treatment technique and tools and d) operator-related factors. While blood vessel and tgthro thrombus-related factors are mostly non-modifiable in the acute setting, operator and technique-related factors can be modified, and extensive research is currently being done to investigate the complex interplay of all these variables, and to optimize the modifiable factors to the maximum possible extent. In this review, we will describe these factors and how they interact with each other in detail, and outline some of their practical implications. We will conclude with a short summary and outlook on future directions for optimizing endovascular treatment success.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34419825&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/j.jbiomech.2021.110694
dc.subjectClot
dc.subjectStroke biomechanics
dc.subjectThrombus
dc.subjectBiomechanics
dc.subjectCardiovascular Diseases
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectRadiology
dc.titleA clinical perspective on endovascular stroke treatment biomechanics
dc.typeJournal Article
dc.source.journaltitleJournal of biomechanics
dc.source.volume127
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/655
dc.identifier.contextkey26341536
html.description.abstract<p>Acute ischemic stroke (AIS) is caused by blockage of an arterial blood vessel in the brain by a thrombus, which interrupts oxygen supply to the brain parenchyma. The goal of endovascular stroke treatment (mechanical thrombectomy) is to restore blood flow as quickly and completely as possible. There are numerous factors that influence endovascular treatment success. They can be broadly grouped into a) factors related to blood vessels, b) factors related to the thrombus, c) factors related to endovascular treatment technique and tools and d) operator-related factors. While blood vessel and tgthro thrombus-related factors are mostly non-modifiable in the acute setting, operator and technique-related factors can be modified, and extensive research is currently being done to investigate the complex interplay of all these variables, and to optimize the modifiable factors to the maximum possible extent. In this review, we will describe these factors and how they interact with each other in detail, and outline some of their practical implications. We will conclude with a short summary and outlook on future directions for optimizing endovascular treatment success.</p>
dc.identifier.submissionpathradiology_pubs/655
dc.contributor.departmentDepartment of Radiology
dc.source.pages110694


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