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Development and testing of a single frequency terahertz imaging system for breast cancer detection

dc.contributor.authorSt Peter, Benjamin
dc.contributor.authorYngvesson, Sigfrid
dc.contributor.authorSiqueira, Paul
dc.contributor.authorKelly, Patrick
dc.contributor.authorKhan, Ashraf
dc.contributor.authorGlick, Stephen J.
dc.contributor.authorKarellas, Andrew
dc.date2022-08-11T08:10:50.000
dc.date.accessioned2022-08-23T17:21:43Z
dc.date.available2022-08-23T17:21:43Z
dc.date.issued2013-07-01
dc.date.submitted2014-12-23
dc.identifier.citationIEEE J Biomed Health Inform. 2013 Jul;17(4):785-97. doi: 10.1109/JBHI.2013.2267351. <a href="http://dx.doi.org/10.1109/JBHI.2013.2267351">Link to article on publisher's site</a>
dc.identifier.issn2168-2194 (Linking)
dc.identifier.doi10.1109/JBHI.2013.2267351
dc.identifier.pmid25055306
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48586
dc.description.abstractThe ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25055306&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110643/
dc.subjectBioimaging and Biomedical Optics
dc.subjectBiological and Chemical Physics
dc.subjectDiagnosis
dc.subjectInvestigative Techniques
dc.subjectMedical Biophysics
dc.subjectNeoplasms
dc.subjectRadiology
dc.titleDevelopment and testing of a single frequency terahertz imaging system for breast cancer detection
dc.typeJournal Article
dc.source.journaltitleIEEE journal of biomedical and health informatics
dc.source.volume17
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/74
dc.identifier.contextkey6488693
html.description.abstract<p>The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.</p>
dc.identifier.submissionpathradiology_pubs/74
dc.contributor.departmentDepartment of Radiology
dc.source.pages785-97


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