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    Imaging the pancreatic vasculature in diabetes models

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    Authors
    Medarova, Zdravka
    Greiner, Dale L.
    Ifediba, Marytheresa
    Dai, Guangping
    Bolotin, Elijah
    Castillo, Gerardo
    Bogdanov, Alexei A. Jr.
    Kumar, Mohanraja
    Moore, Anna
    UMass Chan Affiliations
    Program in Molecular Medicine
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2011-11-10
    Keywords
    Animals
    Diabetes Mellitus, Experimental
    Fluorescein-5-isothiocyanate
    Gadolinium DTPA
    Magnetic Resonance Imaging
    Mice
    Pancreas
    Rats
    Endocrine System
    Endocrine System Diseases
    Investigative Techniques
    Radiology
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721374/
    Abstract
    BACKGROUND: Vascular parameters, such as vascular volume, flow, and permeability, are important disease biomarkers for both type 1 and type 2 diabetes. Therefore, it is essential to develop approaches to monitor the changes in pancreatic microvasculature non-invasively. METHODS: Here, we describe the application of the long-circulating, paramagnetic T1 contrast agent, protected Graft Copolymer bearing covalently linked gadolinium diethylenetriaminepentaacetic acid residues and labelled with fluorescein (PGC-GdDTPA-F) for the non-invasive semi-quantitative evaluation of vascular changes in diabetic models using magnetic resonance imaging. RESULTS: We observed a significantly higher accumulation of protected graft copolymer bearing covalently linked gadolinium diethylenetriaminepentaacetic acid residues and labelled with fluorescein in the pancreata of BBDR rats induced to develop diabetes, as compared to non-diabetic controls at 1 h post-injection. No differences were seen in the blood pool, kidney, or muscle, indicating that the effect is specific to the diabetic pancreas. Fluorescence microscopy revealed a marked increase in contrast agent availability in the pancreas with the development of the pathology. Similar changes were noted in the homozygous Leprdb mouse model of type 2 diabetes. This effect appeared to result both from the increase of vascular volume and permeability. CONCLUSIONS: High-molecular weight paramagnetic blood volume contrast agents are valuable for the in vivo definition of pancreatic microvasculature dynamics by magnetic resonance imaging. The increase in vascular volume and permeability, associated with diabetic inflammation, can be monitored non-invasively and semi-quantitatively by magnetic resonance imaging in diabetic BBDR rats. This imaging strategy represents a valuable research tool for better understanding of the pathologic process.
    Source
    Diabetes Metab Res Rev. 2011 Nov;27(8):767-72. doi: 10.1002/dmrr.1249. Link to article on publisher's site
    DOI
    10.1002/dmrr.1249
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48597
    PubMed ID
    22069257
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/dmrr.1249
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